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dc.contributor.advisorBryda, Elizabeth C.eng
dc.contributor.authorBouvrette, Denise Jo.eng
dc.date.issued2009eng
dc.date.submitted2009 Falleng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on January 25, 2011).eng
dc.descriptionThesis advisor: Dr. Elizabeth Bryda.eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionPh. D. University of Missouri--Columbia 2009.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Genetics area program.eng
dc.description.abstractPolycystic kidney disease (PKD) is a common inherited disorder affecting 600,000 Americans and more than 12 million people worldwide. Clinical manifestations include renal enlargement, abnormal tubular development and accumulative cyst formation. PKD is the leading cause of end stage renal disease in adults and children. Currently, there is no cure for PKD and treatment is limited to dialysis and transplantation. The molecular mechanisms involved in cystogenesis remain unclear. Bicaudal C (Bicc1) is the disease-causing gene in the juvenile congenital polycystic kidney (jcpk) mouse model for PKD. The function of Bicc1 is unknown; however the Bicc1 protein contains two conserved functional domains, three K-homology (KH) domains which are known to bind RNA and a sterile alpha motif (SAM) domain which are predicted to participate in protein-protein interactions. We hypothesize that Bicc1 plays an integral role in normal kidney development. In this study, we investigated in vitro RNA and protein interactions of the Bicc1 protein and generated an alternative, comparative zebrafish model to further study the function of Bicc1 in vivo.eng
dc.format.extentvii, 215 pageseng
dc.identifier.oclc698244973eng
dc.identifier.urihttps://hdl.handle.net/10355/9878
dc.identifier.urihttps://doi.org/10.32469/10355/9878eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2009 Freely available dissertations (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2009 Dissertationseng
dc.subjectsterile alpha motif (SAM) ;protein bicaudal C (Bicc1)eng
dc.subject.lcshPolycystic kidney diseaseeng
dc.subject.lcshMice as laboratory animalseng
dc.subject.lcshRNAeng
dc.titleInvestigation of the biological role of the polycystic kidney disease protein bicaudal C (Bicc1) using comparative animal modelseng
dc.typeThesiseng
thesis.degree.disciplineGenetic Area Program (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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