dc.contributor.advisor | Bryda, Elizabeth C. | eng |
dc.contributor.author | Bouvrette, Denise Jo. | eng |
dc.date.issued | 2009 | eng |
dc.date.submitted | 2009 Fall | eng |
dc.description | The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. | eng |
dc.description | Title from PDF of title page (University of Missouri--Columbia, viewed on January 25, 2011). | eng |
dc.description | Thesis advisor: Dr. Elizabeth Bryda. | eng |
dc.description | Vita. | eng |
dc.description | Ph. D. University of Missouri--Columbia 2009. | eng |
dc.description.abstract | Polycystic kidney disease (PKD) is a common inherited disorder affecting 600,000 Americans and more than 12 million people worldwide. Clinical manifestations include renal enlargement, abnormal tubular development and accumulative cyst formation. PKD is the leading cause of end stage renal disease in adults and children. Currently, there is no cure for PKD and treatment is limited to dialysis and transplantation. The molecular mechanisms involved in cystogenesis remain unclear. Bicaudal C (Bicc1) is the disease-causing gene in the juvenile congenital polycystic kidney (jcpk) mouse model for PKD. The function of Bicc1 is unknown; however the Bicc1 protein contains two conserved functional domains, three K-homology (KH) domains which are known to bind RNA and a sterile alpha motif (SAM) domain which are predicted to participate in protein-protein interactions. We hypothesize that Bicc1 plays an integral role in normal kidney development. In this study, we investigated in vitro RNA and protein interactions of the Bicc1 protein and generated an alternative, comparative zebrafish model to further study the function of Bicc1 in vivo. | eng |
dc.description.bibref | Includes bibliographical references. | eng |
dc.format.extent | vii, 215 pages | eng |
dc.identifier.oclc | 698244973 | eng |
dc.identifier.uri | https://doi.org/10.32469/10355/9878 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/9878 | |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.rights | OpenAccess. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | |
dc.subject | sterile alpha motif (SAM) ;protein bicaudal C (Bicc1) | eng |
dc.subject.lcsh | Polycystic kidney disease | eng |
dc.subject.lcsh | Mice as laboratory animals | eng |
dc.subject.lcsh | RNA | eng |
dc.title | Investigation of the biological role of the polycystic kidney disease protein bicaudal C (Bicc1) using comparative animal models | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Genetic area program (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Doctoral | eng |
thesis.degree.name | Ph. D. | eng |