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dc.contributor.advisorKosztin, Ioaneng
dc.contributor.authorBarz, Bogdan, 1979-eng
dc.date.issued2009eng
dc.date.submitted2009 Falleng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on January 28, 2011).eng
dc.descriptionThesis advisor: Dr. Ioan Kosztin.eng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionPh. D. University of Missouri--Columbia 2009.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Physics.eng
dc.description.abstractThis thesis describes four distinct studies (involving a variety of concepts and methods from the physical sciences) of complex biological systems and processes that cover a wide range of time and length scales (extending from the molecular to the multi-cellular level), namely: 1) identification of near-native structures from a large set of in silico predicted structures for a given target protein by probing the stability of the structures against simulated heating using Molecular Dynamics (MD) simulations; 2) all atom MD simulation study of protein-cell membrane interactions designed to elucidate the relation between the conformational structure of the GP41 fusion peptide of HIV-1 virus and the density of the lipid membrane; 3) calculation of the potential of mean force for water transport through single wall carbon nanotubes from nonequilibrium MD simulations; and 4) development and application of a novel computational method, referred to as the cellular particle dynamics (CPD) method, for the simulation of the dynamics of multicellular systems.eng
dc.format.extentxii, 96 pageseng
dc.identifier.oclc698723600eng
dc.identifier.otherBarzB-012811-D1199eng
dc.identifier.urihttp://hdl.handle.net/10355/9884eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2009 Dissertationseng
dc.subject.lcshMolecular dynamicseng
dc.subject.lcshBiological systems -- Mathematical modelingeng
dc.subject.lcshBiological systems -- Computer simulationeng
dc.titleTheoretical and in silico modeling of biological systems: from protein structure prediction to cellular dynamicseng
dc.typeThesiseng
thesis.degree.disciplinePhysics (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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