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dc.contributor.advisorKosztin, Ioanen_US
dc.contributor.authorBarz, Bogdan, 1979-en_US
dc.date.issued2009eng
dc.date.submitted2009 Fallen_US
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.en_US
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on January 28, 2011).en_US
dc.descriptionThesis advisor: Dr. Ioan Kosztin.en_US
dc.descriptionVita.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionPh. D. University of Missouri--Columbia 2009.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Physics.en_US
dc.description.abstractThis thesis describes four distinct studies (involving a variety of concepts and methods from the physical sciences) of complex biological systems and processes that cover a wide range of time and length scales (extending from the molecular to the multi-cellular level), namely: 1) identification of near-native structures from a large set of in silico predicted structures for a given target protein by probing the stability of the structures against simulated heating using Molecular Dynamics (MD) simulations; 2) all atom MD simulation study of protein-cell membrane interactions designed to elucidate the relation between the conformational structure of the GP41 fusion peptide of HIV-1 virus and the density of the lipid membrane; 3) calculation of the potential of mean force for water transport through single wall carbon nanotubes from nonequilibrium MD simulations; and 4) development and application of a novel computational method, referred to as the cellular particle dynamics (CPD) method, for the simulation of the dynamics of multicellular systems.en_US
dc.format.extentxii, 96 pagesen_US
dc.identifier.oclc698723600en_US
dc.identifier.otherBarzB-012811-D1199en_US
dc.identifier.urihttp://hdl.handle.net/10355/9884
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2009 Freely available dissertations (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2009 Dissertations
dc.subject.lcshMolecular dynamicsen_US
dc.subject.lcshBiological systems -- Mathematical modelingen_US
dc.subject.lcshBiological systems -- Computer simulationen_US
dc.titleTheoretical and in silico modeling of biological systems: from protein structure prediction to cellular dynamicsen_US
dc.typeThesisen_US
thesis.degree.disciplinePhysicsen_US
thesis.degree.disciplinePhysicseng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePh. D.en_US


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