Which medications benefit patients with diastolic heart failure?

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Which medications benefit patients with diastolic heart failure?

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/9949

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Title: Which medications benefit patients with diastolic heart failure?
Author: Crouse, Micah; Flack, David; Kerns, J. William; Martin, Larisa; Pham, Daniel; Sudireddy, Ramashilpa; Knight, Karen
Keywords: ejection fraction
systolic function
Date: 2011-02
Publisher: Family Physicians Inquiries Network
Citation: Journal of Family Practice, 60(2) 2011: 101+.
Series/Report no.: Clinical Inquiries;vol. 60, no. 2, 2010
Abstract: Angiotensin-converting enzyme inhibitors (ACEIs), propranolol, statins, furosemide, and some angiotensin receptor blockers (ARBs) benefit patients. Medications that reduce mortality in diastolic heart failure include ACEIs (strength of recommendation [SOR]: C, 1 prospective cohort trial with matched controls), propranolol (SOR: B, 1 randomized controlled trial [RCT]), and statins (SOR: C, 1 prospective cohort trial). Furosemide improves symptoms of heart failure and quality of life (SOR: C, 1 RCT, using cohort data). ARBs show mixed results: candesartan decreases hospital admissions (SOR: B, 1 large RCT); losartan improves exercise duration and quality of life (SOR: B, 2 small RCTs); irbesartan doesn't improve heart failure symptoms or other outcomes (SOR: B, 1 large RCT).
URI: http://hdl.handle.net/10355/9949

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