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dc.contributor.authorBigsby, Roberteng
dc.contributor.authorChapin, Robert E.eng
dc.contributor.authorDaston, George P.eng
dc.contributor.authorDavis, Barbara J.eng
dc.contributor.authorGorski, Jackeng
dc.contributor.authorGray, L. Earleng
dc.contributor.authorHowdeshell, Kembra L. (Kembra Lynne), 1968-eng
dc.contributor.authorZoeller, R. Thomaseng
dc.contributor.authorvom Saal, Frederick S.eng
dc.date.issued1999eng
dc.descriptionReproduced with permission from Environmental Health Perspectives.eng
dc.description.abstractThe major concerns with endocrine disruptors in the environment are based mostly on effects that have been observed on the developing embryo and fetus. The focus of the present manuscript is on disruption of three hormonal systems: estrogens, androgens, and thyroid hormones. These three hormonal systems have been well characterized with regard to their roles in normal development, and their actions during development are known to be perturbed by endocrine-disrupting chemicals. During development, organs are especially sensitive to low concentrations of the sex steroids and thyroid hormones. Changes induced by exposure to these hormones during development are often irreversible, in contrast with the reversible changes induced by transient hormone exposure in the adult. Although it is known that there are differences in embryonic/fetal/neonatal versus adult endocrine responses, minimal experimental information is available to aid in characterizing the risk of endocrine disruptors with regard to a number of issues. Issues discussed here include the hypothesis of greater sensitivity of embryos/fetuses to endocrine disruptors, irreversible consequences of exposure before maturation of homeostatic systems and during periods of genetic imprinting, and quantitative information related to the shape of the dose-response curve for specific developmental phenomena.eng
dc.identifier.citationBigsby, R, Chapin, R. E., Daston, G. P., Davis, B. J., Gorski, J., Gray, L. E., Howdeshell, K. L., Zoeller, R. T., and vom Saal, F. S. (1999). Evaluating the effects of endocrine disruptors on endocrine function during development. Environmental Health Perspectives 107(Suppl. 4), 613-618.eng
dc.identifier.urihttp://hdl.handle.net/10355/9976eng
dc.languageEnglisheng
dc.publisherNational Institute of Environmental Health Scienceseng
dc.relation.ispartofBiological Sciences publications (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. College of Arts and Sciences. Division of Biological Scienceseng
dc.source.harvestedhttp://ehp.niehs.nih.gov/members/1999/suppl-4/613-618bigsby/bigsby-full.htmleng
dc.subject.lcshEndocrine disrupting chemicalseng
dc.subject.lcshDevelopmental biologyeng
dc.subject.lcshFetus -- Developmenteng
dc.titleEvaluating the Effects of Endocrine Disruptors on Endocrine Function during Developmenteng
dc.typeArticleeng


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