RSS 1.0Pharmaceutical Sciences Electronic Theses and Dissertations (UMKC)
The items in this collection are the theses and dissertations written by students of the Division of Pharmaceutical Sciences. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Kansas City. Click on one of the browse buttons above for a complete listing of the works.
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Development of Closomer And MIBG based Nanoformulation: Application to HIV Prevention and Neuroblastoma Therapy
(2023)This dissertation is divided into two parts. Part #1 focuses on the development and characterization of closomer based nanoformulation for the prevention of HIV/AIDS sexual transmission. Part #2 focuses on the development ... -
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a gram-positive bacteria, the peptidoglycan layer is thick as compared to gram negatives ... -
Functional Analysis of TET-Family 5-Methylcytosine Dioxygenases in Non-CpG DNA Demethylation
(2023)One of the most widely studied epigenetic marks in DNA is 5-methylcytosine (5mC). Research has indicated that in the mammalian genome around 5-6% of all cytosines are methylated (5mC), with a strong preference for the CpG ... -
Alcohol/HIV-Induced Neurodeficit and Circumvention by Neuroprotective Agent
(2023)Alcohol Use Disorder (AUD) remains a major problem in the United States, with usage varying between acute (binge) and chronic (heavy usage) staging. Alcohol Use Disorders affect 14.5 million people, with 9 million men and ... -
Amphetamine-Induced Toxicity in Astrocytes and its Implications in the Pathogenesis of Psychiatric Disorders
(2022)Amphetamine-type stimulants (ATS), such as amphetamine (AMPH) and methamphetamine (METH), cause long-term toxic effects on the dopaminergic neurons in the brain leading to the development of several psychiatric disorders. ... -
Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
(2022)Liquid chromatography-tandem mass spectrometry (LC-MS/MS) based methods for quantifying cell wall biosynthesis intermediates. These include LC-MS/MS methods for quantifying cytoplasmic UDP-linked peptidoglycan biosynthesis ... -
Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
(2022)In the last few decades cancer immunotherapy has emerged as a standard pillar of cancer treatment. Immune checkpoint inhibitors that are currently available target the adaptive immune system, generating T-cell antitumor ... -
Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
(University of Missouri -- Kansas City, 2018)Prostate cancer is the most common male malignancy and remains the second-leading cause of death due to cancer in American men. While surgery and radiation are effective in prostate cancer therapy at early stages, the ... -
Smart hydrogel for enzyme responsive vaginal delivery of anti-HIV peptide therapeutics
(2021)In response to an urgent need for advanced formulations for the delivery of anti-retrovirals, a stimuli sensitive hydrogel formulation that intravaginally delivers HIV-1 entry inhibitor upon being exposed to a specific ... -
Novel nanocarriers to improve drug delivery for age-related macular degeneration
(2021)Visual impairment affecting the posterior segment of the eye is a significant health problem causing a deterioration of the quality of life of millions worldwide. Age-related macular degeneration (AMD) is ranked third on ... -
Enhanced Etoposide Solubility and Anticancer Activity using Complexation and Nanotechnology
(2021)Etoposide is a first line treatment for different cancer types that can be used either alone or in combination with other therapeutic agents. However, systemic toxicity, variable oral bioavailability, and high drug resistance ... -
Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
(2021)PART I: SELF-ASSEMBLING TACROLIMUS NANOMICELLES FOR BACK OF THE EYE DISEASES Vrinda Gote, Candidate for the Doctor of Philosophy Degree University of Missouri-Kansas City, 2021 ABSTRACT Neovascular age-related ... -
Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
(University of Missouri -- Kansas City, 2018)The objective of this dissertation is to develop various systems to deliver small interfering RNA (siRNA) for the treatment of triple negative breast cancer (TNBC) and liver fibrosis. siRNAs targeting vascular endothelial ... -
Evaluation of the Anti-Fibrotic Activity of PCBP2 siRNA in Primary Hepatic Stellate Cells and Discovery of Anti-PD-L1 Peptide and Nanobody for Immunotherapy
(University of Missouri -- Kansas City, 2018)There are two major research objectives in this dissertation. Our laboratory recently discovered a small interfering RNA (siRNA) that silences the poly (rC) binding protein 2 (PCBP2) gene. It is hypothesized that silencing ... -
Establishing Metronidazole as a Novel Biomarker of CYP2A6 Activity
(University of Missouri -- Kansas City, 2018)CYP2A6 is a polymorphically expressed enzyme with variation associated with smoking behavior, cessation success, lung cancer risk, and differential drug exposure to numerous medications including anti-infectious and ... -
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)There are twenty standard amino acids which are proteinogenic and can exist in two stereoisomeric forms, D- and L-enantiomers, except for glycine, which is achiral. The D-amino acids are not incorporated in proteins; ... -
Second Generation Photoactivated Insulins
(2020)The photoactivated depot (PAD) is a minimally invasive approach developed for a continuously variable light stimulated release of insulin. In this approach, a protein depot that can last for days is injected under the skin. ... -
Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma
(2020)Dense desmoplastic stroma is a fundamental characteristic of pancreatic ductal adenocarcinoma (PDAC) and comprises up to 80% of the tumor mass, which acts as a barrier that impedes the delivery of antitumor drugs into the ... -
Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
(2020)Disorders affecting the posterior segment of eyes represent a significant burden to healthcare and patients’ wellbeing. Among the back of the eye disorders, age-related macular degeneration (AMD) is one of the major ailments ... -
Synthesis, Characterization and In-vivo Testing of Photoactivatable Insulin Depots for Continuously Variable and Minimally Invasive Insulin Delivery
(University of Missouri -- Kansas City, 2019)Proteins are macromolecules involved in a diverse array of functions. Mutations or abnormal levels of proteins are indicated in several diseases. Despite showing early promise, the translation of protein therapeutics ...