Browsing Pharmaceutical Sciences Electronic Theses and Dissertations (UMKC) by Thesis Semester "2012 Fall"
Now showing items 1-5 of 5
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Development of drug conjugates in cancer therapy and evaluation of dual siRNA silencing effect on breast cancer growth and invasion
(University of Missouri--Kansas City, 2012)The objective of this dissertation is to present various approaches for treatment cancer, which is the leading cause of death worldwide. Compared to other disease, cancer has many unique biological characteristics that ... -
Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
(University of Missouri--Kansas City, 2012)The objective of this dissertation is to develop siRNA-based cancer therapeutics. In chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based therapy, as well as various siRNA delivery systems. ... -
Molecular assembly of polycyanoarenes with silver salts and synthesis of polycyclic aromatic hydrocarbonds
(University of Missouri--Kansas City, 2012)This dissertation encompasses the investigation of two distinct subjects. In the first part, which is in the area of molecular self-assembly, the complexation of organonitrile aryl compounds with three different types ... -
Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
(University of Missouri--Kansas City, 2012)Pentablock copolymers comprised of multi-polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for fabrication of nanoparticles and thermosensitive hydrogel ... -
Role of cytochrome P450 enzymes on alcohol/nicotine-mediated oxidative stress and cytotoxicity in monocytes/astrocytes: Implications for HIV-infected alcohol/tobacco users
(University of Missouri--Kansas City, 2012)Alcohol abuse is known to induce liver diseases and neurodegeneration. Chronic alcohol use during medication is known to decrease drug efficacy and increase toxicity. In addition, alcohol is known to interact with other ...