Browsing Pharmaceutical Sciences Electronic Theses and Dissertations (UMKC) by Thesis Semester "2014 Fall"
Now showing items 1-8 of 8
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Characterization of the Organic Matrix of Mature Human Tooth Enamel: Structure, Macromolecular Composition and Effect of Radiotherapy
(2014-09-30)Mature human tooth enamel contains a small amount of organic matrix locally concentrated within its innermost region, which is tougher and more crack resistant than the outer bulk phase. Although the enamel organic matrix ... -
Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
(2014-08-28)The research presented in this dissertation is aimed at understanding the epigenetic regulation of the HIF pathway and the efficacy of treatment for retinal diseases and hemangioblastomas using HIF pathway inhibitors. ... -
Evaluation of siRNA mediated Silencing of IKKα in Prostate cancer and CD40 in Type-1 Diabetes
(2014-09-30)The objective of this dissertation is to present the various therapeutic approaches for two distinctly different diseases, prostate cancer and type-1 diabetes. Our objective (1) for prostate cancer is to evaluate the siRNA ... -
Novel Polycyclic Benzannulated Indole Scaffolds via Indole Aryne Cycloaddition, Pd (0)-Catalyzed Cross-coupling and ROM/RCM methodologies: Their Applications to Library Development and Drug Discovery
(2014)Dissertation under the direction of Keith R. Buszek, Ph.D., Professor of Chemistry, University of Missouri-Kansas City. Heterocyclic chemistry is one of the most valuable sources of novel compounds with diverse biological ... -
Preparation Of Oligonucleotide Delivery Agents And Insulin Depot Materials Using Solid Phase Synthesis
(2014)Short interfering RNA (siRNA) induced RNA interference (RNAi) is capable of preventing gene translation. In a laboratory setting, various transfection methods have enabled this mechanism to be used for routine gene silencing ... -
Prodrug Approach to Improve Oral and Brain Absorption of HIV Protease Inhibitor, Lopinavir
(2014)The main objective of this project is to develop prodrug strategies to circumvent efflux pumps such as P-glycoprotein (P-gp) and multidrug resistance associated proteins (MRPs), thereby enhancing oral and brain absorption ... -
Proinflammatory Cytokine / Chemokine Expression in Human Astrocytes: Induction by HIV-1 Nef
(2014)The mortality and morbidity of HIV-1 infected individuals were declined significantly by the introduction of highly active antiretroviral therapy (HAART). Nevertheless, different forms of HIV-associated neurocognitive ... -
Resveratrol Analogs: Potential Chemopreventive Agents in Breast Cancer
(2015-05-22)Epidemiological data and studies in rodent models strongly support the role of estrogens in the development of breast cancers. Estrogens have been added to the list of known human carcinogens. Exact mechanisms underlying ...