Chemistry Electronic Theses and Dissertations (UMKC)
The items in this collection are the theses and dissertations written by students of the Department of Chemistry. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Kansas City. Click on one of the browse buttons above for a complete listing of the works.
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Development of Closomer And MIBG based Nanoformulation: Application to HIV Prevention and Neuroblastoma Therapy
(2023)This dissertation is divided into two parts. Part #1 focuses on the development and characterization of closomer based nanoformulation for the prevention of HIV/AIDS sexual transmission. Part #2 focuses on the development ... -
Design, Preparation, And Applications Of Novel N-Vinyliminium Salts in Organic Synthesis. Design and Synthesis of Tau Aggregate-specific Fluorescent Probes for Postmortem Imaging of Brains with Tauopathies
(2023)PART I Efforts to optimize the electrophilic coupling partners for the Suzuki reaction by electronically and sterically tuning the pyridinium moiety are described. Both reaction temperature and catalyst loading have been ... -
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a gram-positive bacteria, the peptidoglycan layer is thick as compared to gram negatives ... -
Chemical Surface Modification of Polycarbonate to Increase Hydrophilicity
(2023)Polycarbonate, commonly used in glasses lenses, is prone to fogging. Fogging can be reduced by modifying the structure of polycarbonate to be more hydrophilic, ideally superhydrophilic with a contact angle less than 10°. ... -
Development and Evaluation of 3D-Printed Cardiovascular Stents
(2022)Biodegradable stents (BDS) could be a promising alternative to the conventional metallic stents for the treatment of atherosclerosis which is a coronary artery disease (CAD). Three-dimensional (3D) printing technique has ... -
Ab Initio Density Functional Theory Optimized Geometries of Vinyl Trialkylammonium, Vinylpyridinium and Vinyldiazonium Tetrafluoroborate Salts with Natural Bond Orbital Charge Distributions in the Gas Phase
(2022)N-Vinyltrialkylammonium and N-vinylimmonium tetrafluoroborate salts are novel classes of compounds discovered by Buszek and Jung. They were originally used as dienophiles and as ß-dialkylamino equivalents in Diels-Alder ... -
Electrochemical Analysis of Oxidation of Primary Amines to Ketones with 3,5-Di-Tert-Butyl-1,2Benzoquinone
(2022)Electrochemical techniques have been used extensively to study electrode reactions and the coupled chemical-electrochemical reactions. Moreover, the concentration of redox active species in many of the redox reactions ... -
Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
(2022)Liquid chromatography-tandem mass spectrometry (LC-MS/MS) based methods for quantifying cell wall biosynthesis intermediates. These include LC-MS/MS methods for quantifying cytoplasmic UDP-linked peptidoglycan biosynthesis ... -
Chemical and biochemical applications of vibrational spectroscopy
(2022)Vibrational spectroscopy is a technique that probes a molecule’s vibrational modes via infrared absorption and Raman scattering, and is often used as a tool for characterization and/or functional group determination. Because ... -
Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
(2022)In the last few decades cancer immunotherapy has emerged as a standard pillar of cancer treatment. Immune checkpoint inhibitors that are currently available target the adaptive immune system, generating T-cell antitumor ... -
Ab Initio Density Functional Theory Charge Distributions of Vinyltrimethylphosphonium, Vinylphosphorinium, and Vinyldiphosphonium Tetrafluoroborate Salts with Mechanistic Studies of Phospha-Michael Additions to Activated Acetylenes
(2022)While vinylammonium and vinylpyridinium tetrafluoroborate salts have previously been well investigated by the Buszek research group in their applications to Diels-Alder and other reactions, very little is known about their ... -
Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
(University of Missouri -- Kansas City, 2018)Prostate cancer is the most common male malignancy and remains the second-leading cause of death due to cancer in American men. While surgery and radiation are effective in prostate cancer therapy at early stages, the ... -
Hydrolysis and aqueous corrosion of silicate and aluminosilicate glasses via ab initio molecular dynamics simulation
(2021)Hydrolysis and aqueous corrosion of glass is a complex and puzzling phenomenon. Although many endeavors have been made to investigate corrosion in glass, it is still an open question with many unanswered fundamental issues. ... -
Aminoxyl Catalyzed Electrochemical Ethanol Detection: Development of a New Breathalyzer Using Molecular Catalysis
(2021)Blood alcohol concentration (BAC) is the indicator of alcohol intoxication, and its measurement has emerged as the most common analytical procedure requested by law enforcement. Due to its volatility, ethanol vapor can be ... -
Smart hydrogel for enzyme responsive vaginal delivery of anti-HIV peptide therapeutics
(2021)In response to an urgent need for advanced formulations for the delivery of anti-retrovirals, a stimuli sensitive hydrogel formulation that intravaginally delivers HIV-1 entry inhibitor upon being exposed to a specific ... -
Novel nanocarriers to improve drug delivery for age-related macular degeneration
(2021)Visual impairment affecting the posterior segment of the eye is a significant health problem causing a deterioration of the quality of life of millions worldwide. Age-related macular degeneration (AMD) is ranked third on ... -
Enhanced Etoposide Solubility and Anticancer Activity using Complexation and Nanotechnology
(2021)Etoposide is a first line treatment for different cancer types that can be used either alone or in combination with other therapeutic agents. However, systemic toxicity, variable oral bioavailability, and high drug resistance ... -
Chirality directed self-assembly: in situ construction of recyclable and reusable Janus dendrimers
(2021)The underlying theme at the forefront of synthetic organic chemistry has always been about compounding simple precursors into more complex molecular targets. However, this strenuous process often involves the generation ... -
Amorphous hydrogenated boron carbide for solid-state direct-conversion thermal neutron detection
(2021)Amorphous hydrogenated boron carbide (a-BC:H) is one of a very limited number of neutron-sensitive materials. It has been studied over the last three decades for solid-state thermal neutron detection due to its high ... -
Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
(University of Missouri -- Kansas City, 2018)The objective of this dissertation is to develop various systems to deliver small interfering RNA (siRNA) for the treatment of triple negative breast cancer (TNBC) and liver fibrosis. siRNAs targeting vascular endothelial ...