RSS 1.0Chemistry Electronic Theses and Dissertations (UMKC)
The items in this collection are the theses and dissertations written by students of the Department of Chemistry. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Kansas City. Click on one of the browse buttons above for a complete listing of the works.
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Recent Submissions
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Recent Advances in Hetaryne Chemistry. Efforts Toward the Development of a Single Platform for the Generation of 4,5-, 5,6-, and 6,7-Indole Arynes
(University of Missouri--Kansas City, 2017)In the beginning of 2007, indole arynes and their cycloaddition chemistry were discovered by Buszek laboratories. Since then, indole arynes and their cycloaddition chemistry have demonstrated their value in the ... -
Practical Applications of Infrared, Raman and Nuclear Magnetic Resonance Spectroscopic Techniques for Qualitative, Quantitative and Structural Analysis of Pharmaceutical Drugs, Cementitious Material and Organic Molecules Containing Phosphorous
(University of Missouri--Kansas City, 2016)The study of the interaction between matter and electromagnetic radiation which procreated the wide branch named as Spectroscopy has gained tremendous attention since the last century. Atoms and molecules respond to ... -
Growth of Semiconductor Thin Films by Pulsed Laser Deposition
(University of Missouri--Kansas City, 2016)Pulsed ultraviolet light from a XeF excimer laser was used to grow thin films of zinc oxide and tin dioxide on (111) p-type silicon wafers within a versatile high vacuum laser deposition system. This pulsed laser deposition ... -
Refinement and Applications of Light Controlled Biological Processes
(University of Missouri–Kansas City, 2015)For understanding of biological processes, a spatiotemporal control over these processes is needed. Controlling these processes using light can give us the advantage of a precise control over spacing, timing and degree of ... -
Asymmetric Positron Annihilation in Chiral Tartrate and Tartaric Acid Crystals
(University of Missouri–Kansas City, 2015)Positron annihilation lifetime spectroscopy (PALS) has been used to study the interactions of positrons with chiral tartaric acids and tartrates. Differences in lifetimes of and its intensity I2 were compared between large ... -
Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, ... -
Development of Advanced Delivery Systems for Microbicides
(2016)HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection due to anatomical and physiological ... -
Conformational and Structural Investigation of Substituted Hydrocarbons and Ring Compounds by Vibrational and Microwave Spectroscopy
(2016)The physiochemical properties of a molecule of interest are usually obtained from its molecular structure, and it involves the orientation of one part of the molecule about a particular bond with respect to the rest ... -
The Study of Initiation Systems and Formulations for the Development of a Novel Silorane Biomaterial
(2015)There are approximately one million hip and knee replacements each year in the United States alone and over 70% are cemented for stabilization. The number of these replacements is expected to rise to 3.5 million per year ... -
Design and Evaluation of HIV Microbicides Loaded mucoadhesive Nanoformulation
(2015)HIV/AIDS had caused more than 25 million deaths since it was first recognized. Women are more susceptible to HIV infection in comparison with men due to human physiology, social, economic disadvantages. To protect women ... -
Studies of Conjugated Small Molecules, Polymers and Organic-Inorganic Hybrid Materials for Photovoltaic Applications
(2015)This dissertation focuses on the photophysical properties and device studies of three different types of materials, namely polyoxometalate (POM)-containing organic-inorganic hybrids, near-IR absorbing conjugated polymers ... -
Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
(2015)Since their discovery in the Buszek laboratories in 2007, the indole arynes and their cycloaddition chemistry has demonstrated its significance in achieving the total synthesis of biologically active indole alkaloid natural ... -
Raman, Infrared and Microwave Spectra, Conformational Stability, R₀ Structural Parameters and Vibrational Assignments of Some Organoamines, Organophosphines, Alcohols And Substituted Four And Five Membered Rings
(2014)The infrared and Raman spectra of compounds with amino, phosphours, silane and hydroxyl functional groups, as well as some with cyclic skeletal structures have been recorded of the gas and in condensed phases. Temperature ... -
Evaluation of therapeutic effect of PCBP2 siRNA on hepatic stellate cells and development of a streptavidin-based siRNA delivery system
(2014)Type I collagen accumulates during liver fibrosis primarily because α-complex protein-2 (αCP2), encoded by the poly(rC) binding protein 2 (PCBP2) gene, binds to the 3′end of the collagen mRNA and increases its half-life. ... -
Development of polymeric nanoparticulate formulation encapsulating protein molecules following hydrophobic ion pairing complexation
(2014)Several formulation strategies have been employed to enable sustained delivery of antibody therapeutics by nanoparticulate based dosage forms. However, development of sustained release nanoparticulate based dosage form for ... -
Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases
(2013)We have successfully synthesized pentablock (PB) copolymers comprised of various FDA approved polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB ... -
Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
(2013)Cidofovir (CDF) has shown potential in vitro and in vivo antiviral activity against cytomegalovirus (CMV) retinitis. However, low CDF permeability due to its hydrophilic nature limits its effectiveness. Furthermore, ... -
Polycyclic Aromatic Hydrocarbon (PAH)-Based Conjugated Macrocycles and Polymers For Electronic Applications
(2014)Due to the high tendency to form π-stacked ordered phases, polycyclic aromatic hydrocarbons (PAHs) are attractive building blocks for the assembly of conjugated systems for electronic applications. The body of this ... -
Preparation Of Oligonucleotide Delivery Agents And Insulin Depot Materials Using Solid Phase Synthesis
(2014)Short interfering RNA (siRNA) induced RNA interference (RNAi) is capable of preventing gene translation. In a laboratory setting, various transfection methods have enabled this mechanism to be used for routine gene silencing ... -
I. Structure-Activity Relationship Studies of 6,7-Annulated-5-Substituted Libraries. II. Current Efforts Towards The Synthesis of 4-Azaindole Aryne Precursors
(2015)A contemporary and highly valued method for drug discovery involves the synthesis of libraries or collections of novel compounds from interesting molecular scaffolds, often inspired by biologically active, naturally occuring ...