RSS 1.0Chemistry Electronic Theses and Dissertations (UMKC)
The items in this collection are the theses and dissertations written by students of the Department of Chemistry. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Kansas City. Click on one of the browse buttons above for a complete listing of the works.
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Recent Submissions
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Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)Pentablock (PB) copolymers have been successfully synthesized for long term delivery in the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA approved biodegradable polymer such as ... -
Positron interactions with oriented polymers and with chiral quartz crystals
(University of Missouri--Kansas City, 2017)Positron annihilation in various materials has been applied to characterize microstructure for decades. In this work, PALS was used to study material nanostructure, with a focus on the size and density of free volume ... -
Conformational Behavior and Structural Parameters of Some Cyclic and Chain Molecules
(University of Missouri--Kansas City, 2017)The physicochemical properties of a molecule derive from its molecular structure, and that structure often involves the orientation of one part of the molecule about a particular bond with respect to the rest of the ... -
Synthesis and Electrocatalytic Properties of Structure Engineered First-Row Transition Metal Derivatives
(University of Missouri--Kansas City, 2018)Hydrogen is a green energy carrier, producing only water when combusted, and a hydrogen economy has been considered the ideal green economy for human society. Water electrolysis can produce high-purity hydrogen on a ... -
First-Principles Calculation of Laser Crystal Multiplet Levels via Hybridized Density Functional Theory and Configuration Interaction within the OLCAO Method
(University of Missouri--Kansas City, 2017)Computation of highly-localized multiplet energy levels of transition metal dopants is essential to the design of materials such as laser host crystals. A purely first-principles density functional theory-configuration ... -
Metals hosts in the Pennsylvanian Hushpuckney and Stark Black Shales from Selected Areas in Kansas City
(University of Missouri--Kansas City, 2017)The Hushpuckney Shale of the Swope Formation and the Stark Shale of the Dennis Formation, two black shales in the Pennsylvanian Kansas City group, contain elevated concentrations of transition and based metal elements, ... -
Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
(University of Missouri--Kansas City, 2016)The objective of this dissertation is to present two approaches to identify Hepatic Stellate Cells (HSCs) targeting ligands using phage-display library biopanning and systematic evolution of ligands by exponential ... -
Metabolomic Analysis of Bacterial Cell Wall Intermediates Using LC-MS/MS: Peptidoglycan Pathway Response to Different Antibiotics
(University of Missouri--Kansas City, 2017)The bacterial cell wall is made up of peptidoglycan (PG) and its synthesis is of interest as a target for several antibiotics and for new inhibitor development. Peptidoglycan biosynthesis is a complex process which ... -
Synthesis, Characterization and Device Studies of Conjugated Foldamers
(University of Missouri--Kansas City, 2017)Conjugated polymers have found a wide range of electronic applications in last few decades due to their superior combination of optoelectronic, mechanical properties, and solution processability. In the past few years, ... -
Novel Approaches for Targeted Delivery of Cancer Therapeutics to Nuclei of Malignant Cells
(University of Missouri--Kansas City, 2016)The primary goal of this project is to increase specific uptake of anti-cancer therapeutics by nuclei of cancer cells. A lot of research has been done to target therapeutics specifically across plasma membrane of ... -
Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention
(University of Missouri--Kansas City, 2016)The objective of this dissertation is to design and optimize a nanoformulations (nanoparticle and nanofiber) delivery system loaded with anti-HIV topical microbicides for HIV prevention in women. In chapters 1 and ... -
Development and Evaluation of Nanocarriers against Atherosclerosis
(University of Missouri--Kansas City, 2016)The objective of this project was to develop advanced nanocarriers such as nanographene and graphene quantum dots against atherosclerosis. Mannosylated-reduced graphene oxide (Man-rGO) was developed as a targeted ... -
Recent Advances in Hetaryne Chemistry. Efforts Toward the Development of a Single Platform for the Generation of 4,5-, 5,6-, and 6,7-Indole Arynes
(University of Missouri--Kansas City, 2017)In the beginning of 2007, indole arynes and their cycloaddition chemistry were discovered by Buszek laboratories. Since then, indole arynes and their cycloaddition chemistry have demonstrated their value in the ... -
Practical Applications of Infrared, Raman and Nuclear Magnetic Resonance Spectroscopic Techniques for Qualitative, Quantitative and Structural Analysis of Pharmaceutical Drugs, Cementitious Material and Organic Molecules Containing Phosphorous
(University of Missouri--Kansas City, 2016)The study of the interaction between matter and electromagnetic radiation which procreated the wide branch named as Spectroscopy has gained tremendous attention since the last century. Atoms and molecules respond to ... -
Growth of Semiconductor Thin Films by Pulsed Laser Deposition
(University of Missouri--Kansas City, 2016)Pulsed ultraviolet light from a XeF excimer laser was used to grow thin films of zinc oxide and tin dioxide on (111) p-type silicon wafers within a versatile high vacuum laser deposition system. This pulsed laser deposition ... -
Refinement and Applications of Light Controlled Biological Processes
(University of Missouri–Kansas City, 2015)For understanding of biological processes, a spatiotemporal control over these processes is needed. Controlling these processes using light can give us the advantage of a precise control over spacing, timing and degree of ... -
Asymmetric Positron Annihilation in Chiral Tartrate and Tartaric Acid Crystals
(University of Missouri–Kansas City, 2015)Positron annihilation lifetime spectroscopy (PALS) has been used to study the interactions of positrons with chiral tartaric acids and tartrates. Differences in lifetimes of and its intensity I2 were compared between large ... -
Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, ... -
Development of Advanced Delivery Systems for Microbicides
(2016)HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection due to anatomical and physiological ... -
Conformational and Structural Investigation of Substituted Hydrocarbons and Ring Compounds by Vibrational and Microwave Spectroscopy
(2016)The physiochemical properties of a molecule of interest are usually obtained from its molecular structure, and it involves the orientation of one part of the molecule about a particular bond with respect to the rest ...