Browsing Chemistry Electronic Theses and Dissertations (UMKC) by Thesis Semester "2013 Fall"
Now showing items 1-7 of 7
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Ab initio computational applications of electronic structure and spectroscopic Properties of bulk Crystalline materials
(2013)Boron-rich compounds and elemental boron have amazing chemical, physical and mechanical properties, but puzzling structures. The uncertain stoichiometric value of foreign elements in boron-rich compounds greatly influences ... -
Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases
(2013)We have successfully synthesized pentablock (PB) copolymers comprised of various FDA approved polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB ... -
EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
(2013)Millions of people worldwide have been infected with human immunodeficiency (HIV). Highly active antiretroviral therapy (HAART) has substantially improved the clinical management of HIV-1 infection. Inclusion of HIV protease ... -
Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
(2013)Cidofovir (CDF) has shown potential in vitro and in vivo antiviral activity against cytomegalovirus (CMV) retinitis. However, low CDF permeability due to its hydrophilic nature limits its effectiveness. Furthermore, ... -
Synthesis and analysis of siloranes for use as a biomaterial and extended twisted molecular ribbons
(2013)The development of complex organic molecules with industrial potential requires meticulous synthetic methodologies coupled with detailed investigations surrounding their physical properties. This dissertation encompasses ... -
Synthesis, self-assembly and applications of tribenzopenta-phene derivatives and triphenylene-based conjugated foldamers
(2013)Polycyclic aromatic hydrocarbons (PAHs) are interesting discotic liquid crystalline materials. Their often planar or near-planar geometry and extended π-delocalization render them appealing π-π stacking building blocks ... -
Total synthesis of (±)-cis-trikentrin B, (±)-herbindole A and (±)-herbindole B. investigation into the regioselectivity of 6,7-Indole aryne cycloadditions
(2013)Total synthesis of benzannulated indole alkaloid natural products (±)-cis-trikentrin B, (±)-herbindole A and (±)-herbindole B via intermolecular indole aryne cycloaddition are described. The 5,6,7-tribromoindole was ...