Browsing Chemistry Electronic Theses and Dissertations (UMKC) by Thesis Advisor "Friedman, Simon H. (Simon Hilary), 1966-"
Now showing items 1-7 of 7
-
Design, synthesis and evaluation of novel intercalator analogs targeting therapeutically important polymerases and folded RNA
(2013)Polymerases and ribonucleic acids have been found to play major roles in the causation and progression of several diseases. Targeting such important therapeutic targets using small molecules can help achieve their specific ... -
Light-activated biomacromolecules
(2013)Biomacromolecules, mainly nucleic acids and proteins, are involved in every cellular process and therefore their aberrant level or function is linked with most of the diseases. Controlling these macromolecules using light ... -
Preparation Of Oligonucleotide Delivery Agents And Insulin Depot Materials Using Solid Phase Synthesis
(2014)Short interfering RNA (siRNA) induced RNA interference (RNAi) is capable of preventing gene translation. In a laboratory setting, various transfection methods have enabled this mechanism to be used for routine gene silencing ... -
Refinement and Applications of Light Controlled Biological Processes
(University of Missouri–Kansas City, 2015)For understanding of biological processes, a spatiotemporal control over these processes is needed. Controlling these processes using light can give us the advantage of a precise control over spacing, timing and degree of ... -
Second Generation Photoactivated Insulins
(2020)The photoactivated depot (PAD) is a minimally invasive approach developed for a continuously variable light stimulated release of insulin. In this approach, a protein depot that can last for days is injected under the skin. ... -
Structural and chemical studies of RNA as anti-cancer target and signaling molecule
(University of Missouri--Kansas City, 2012-01-06)Ribonucleic acids have been found to have a major role in causation and propagation of diseases. Targeting such therapeutically important RNA can be a method of treatment of various diseases. Two such therapeutically ... -
Synthesis, Characterization and In-vivo Testing of Photoactivatable Insulin Depots for Continuously Variable and Minimally Invasive Insulin Delivery
(University of Missouri -- Kansas City, 2019)Proteins are macromolecules involved in a diverse array of functions. Mutations or abnormal levels of proteins are indicated in several diseases. Despite showing early promise, the translation of protein therapeutics ...