Stadler Genetics Symposia, volume 10, 1978 (MU)

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https://hdl.handle.net/10355/66512

Contents of volume 10

Acknowledgements
Contents
Participants
E. R. Sears Scholarship Fund
Arthur Chovnick, Margaret Mccarron, Arthur Hilliker, Janis O'Donnell, William Gelbart and Stephen Clark: ORGANIZATION OF A GENE IN DROSOPHILA: A PROGRESS REPORT
Barbara Mcclintock: MECHANISMS THAT RAPIDLY REORGANIZE THE GENOME
Norman H. Giles, N. K. Alton, M. E. Case, J. A. Hautala, J. W. Jacobson, S. R. Kushner, V. B. Patel, W. R. Reinert, P. Str¢man and D. Vapnek: THE ORGANIZATION OF THE QA GENE CLUSTER IN NEUROSPORA CRASSA AND ITS EXPRESSION IN ESCHERICHIA COLI
Janine Zieg, Michael Silverman,Marcia Hilmen, and Melvin Simon: PHASE VARIATION IN SALMONELLA: ANALYSIS OF THE CONTROLLING ELEMENT OF H2 GENE EXPRESSION
C. S. Levings, III and D. R. Pring: THE MITOCHONDR IAL GENOME OF HIGHER PLANTS
M. M. Green THE GENETIC CONTROL OF MUTATION IN DROSOPHILA
George P. Smith: NON-DARWINIAN EVOLUTION AND THE BEARD OF LIFE
Cumulative Contents of the Proceedings of the Stadler Genetics Symposia

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Stadler Genetics Symposia, volume 10, 1978 : Preliminaries and back matter
(University of Missouri, Agricultural Experiment Station, 1978) Stadler Genetics Symposium (10th : 1978 : Columbia, Missouri)
Phase variation in salmonella : analysis of the controlling element of H2 gene expression : gene expression, recombinational control, phase variation, DNA inversion
(University of Missouri, Agricultural Experiment Station, 1978) Zieg, Janine; Silverman, Michael; Simon, Michael; Stadler Genetics Symposium (10th : 1978 : Columbia, Missouri)
In the phase variation system of Salmonella, the alternative expression of Hl and H2 flagella is controlled by a region of DNA adjacent to the H2 structural gene known as the Phase Determinant. The Phase Determinant regulates H2 gene activity via a site specific recombinational event. Electron microscopic evidence and restriction endonuclease site mapping indicate that the recombinational event results in an inversion of a region of DNA 800 bp (base pairs) in length. The inversion process does not depend on the RecA recombinational pathway of E. coli. Plasmids have been constructed in which the expression of non-related genes appear to be under phase variation control. These plasmids have provided evidence concerning the direction of transcription of the H2 structural gene and the position of the H2 promoter.
Non-Darwinian evolution and the bread of life : genetic drift, repetitive DNA, philosophy of science
(University of Missouri, Agricultural Experiment Station, 1978) Smith, George P.; Stadler Genetics Symposium (10th : 1978 : Columbia, Missouri)
This paper explores what would happen to a chromosomal segment that evolves randomly, without the surveillance of natural selection. In these circumstances a single segment present in some individual organism at any given starting time will eventually spread through the population until it becomes fixed in the entire gene-pool - or more properly the "segment pool". At the same time, the continual deletion, duplication and insertion of nucleotides in a randomly-evolving segment of DNA will lead to fixation of individual nucleotides in the total pool of nucleotides in all the homologous segments in the species. When this genetic drift at the nucleotide level is examined in detail, it is seen to provide a simple, natural solution to a contemporary problem in molecular evolution: the prevalence of apparently functionless segments consisting of simple nucleotide sequences repeated tandemly thousands to millions of times. The solution exemplifies a class of scientific theories that are difficult or impossible to corroborate experimentally, even though they may be intellectually satisfying and of considerable practical importance in the progress of science.
The mitochondrial genome of higher plants : mtiochondrial DNA, cytoplasmic male sterility, S cytoplasm
(University of Missouri, Agricultural Experiment Station, 1978) Levings, C. S., III; Pring, D. R.; Stadler Genetics Symposium (10th : 1978 : Columbia, Missouri)
Mitochondrial (mt) DNAs of higher plants have molecular weights ranging from 70-165 x 10 [superscript 6], which is by far the largest found in nature. Their native configuration is probably a covalently closed circular molecule. In some species, the entire mt genome is coded on a single molecule but in others several classes of mtDNA molecules have been indicated. The informational content of the mt genome of higher plants is poorly determined. The large size predicts that additional information is coded by these mt genomes. Evidence is presented which suggests that cytoplasmic male sterility (cms) is one of the additional traits. Sequence differences have been detected among mt DNAs isolated from plants from different cytoplasmic backgrounds. Although the sequence distinctions are of unknown consequence, it is important because it establishes that diversity exists among mt genomes within a species. Associated with mitochondria from the S cytoplasm of maize are two unique plasmid-like DNAs. Seemingly, these unique DNAs are responsible for the S type of cms as well as the unstable behavior of this cytoplasm.
The genetic control of mutation in drosophila : spontaneous mutation, mutator genes, mitotic recombination
(University of Missouri, Agricultural Experiment Station, 1978) Green, M. M.; Stadler Genetics Symposium (10th : 1978 : Columbia, Missouri)
Mitotic recombination (MR) chromosomes are geographically widespread and occur in high frequency in wild Drosophila melanogaster populations. In both sexes, MR chromosomes increase the frequency of mitotic recombination and act as mutators for specific gene loci. Thus, MR chromosomes strongly influence the spontaneous mutation process.

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