Stadler Genetics Symposia, volume 06, 1974 (MU)
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Contents of volume 6
- PREFACE
- PROGRAM
- CONTENTS
- LIST OF PARTICIPANTS
- G. UNGAR: Molecular Coding of Information in the Nervous System
- O. W. McBRIDE: Metaphase Chromosome Uptake by Mammalian Cells and Expression of the Genes Transferred
- T. T. PUCK: The Genetics of Somatic Mammalian Cells
- R. H. DAVIS: Metabolic Organization in Neurospora
- P. S. CARLSON and T. B. RICE: Developmental Genetics and Crop Yield
- B. A. HAMKALO, O. L. MILLER, Jr. and A. H. BAKKEN: Electronmicroscopic Studies of Active Genes
- C. S . GOWANS: Genetics and Art
- G. P. REDEI, G. ACEDO and G. GAVAZZI: Flower Differentiation in Arabidopsis
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Item Stadler Genetics Symposia, volume 06, 1974 : Preliminaries and back matter(University of Missouri, Agricultural Experiment Station, 1974) Stadler Genetics Symposium (6th : 1974 : Columbia, Missouri)Item Molecular coding of information in the nervous system(University of Missouri, Agricultural Experiment Station, 1974) Ungar, G.; Stadler Genetics Symposium (6th : 1974 : Columbia, Missouri)Evidence has been accumulating in the last ten years to support the existence of a molecular code for the processing of information by the nervous system. The most direct evidence has been provided by the behavioral bioassay approach which has led to the isolation of training - induced and behavior-inducing peptides (mnemones). The most probable role of these peptides is to establish and consolidate the connection sof the neural circuits in which information is stored. Although this coding process is based on the genetically controlled labeling system by which neurons are organized into specific pathways, it must involve a step of non-genetic peptide synthesis.Item Flower differentiation in arabidopsis(University of Missouri, Agricultural Experiment Station, 1974) Rédei, G. P.; Acedo, Georgia; Gavazzi, G.; Stadler Genetics Symposium (6th : 1974 : Columbia, Missouri)There is a consensus among developmental geneticists that few generalizations are possible at the present status of the field, and even the boundaries are difficult to define. Yet in few special cases, consistent facts have been accumulated which point to systems of controls of differentiation.In the facultative long-day plant Arabidopsis, the differentiation of flower primordia is controlled by several gene loci. Recessive mutations may determine in a qualitatively distinct manner the onset of flower development. Continuous illumination in contrast to 8-9 hours daily cycles of light promotes flowering in all genotypes. Mutants at the ld locus are incapable of flowering under short days and entail a critical day-length. Different alleles at the gi locus require several times as long period for flower induction than the wild type under 24 hours light yet under short days they do not differ, very conspicuously from the standard type. Mutants at the co locus are late flowering and recessive under long days but they are more precocious than the wild type under short days and they display dominance. In total darkness, the wild type and all mutants flower early. The aseptic feeding of 5-bromodeoxyuridine highly accelerates flower differentiation in all genotypes under long days and also under short days with the exception of the ld mutants. The analog is incorporated into the DNA of all types. Bromodeoxyuridine-grown plants accumulate higher amounts of radioactivity, provided by 14[subscript C]-amino acids, into a chromatin fraction. The experimental observations support the view that flowering in this plant is under negative control and bromodeoxyuridineis hampering the synthesis of a postulated suppressor.Item The genetics of somatic mammalian cells(University of Missouri, Agricultural Experiment Station, 1974) Puck, Theodore, T.; Stadler Genetics Symposium (6th : 1974 : Columbia, Missouri)Somatic cell genetics is an application of the concepts and techniques of microbial genetics to somatic cells of higher organisms. Applied to mammalian systems, it has made possible clone isolation, quantitation of cell reproduction, establishment of cell survival curves, somatic chromosome analysis, single gene mutations, measurement of mutagenic action, cell hybridization with and without chromosome loss, dominance determination, complementation analysis, synteny determination, and a variety of applications to medicine and to research on genetic control mechanisms.Item Metaphase chromosome uptake by mammalian cells and cxpression of the genes transferred(University of Missouri, Agricultural Experiment Station, 1974) McBride, O. W.; Stadler Genetics Symposium (6th : 1974 : Columbia, Missouri)Isolated metaphase chromosomes can be incorporated into mammalian cells. The genetic information thereby transferred, in the form of a chromosome, can be replicated and expressed in the recipient cell and its progeny, thus resulting in permanent genetic change. Whether this information transfer involves an intact chromosome or merely a fragment, which may be integrated into a host chromosome, has not yet been established. The possible implications of these findings for analysis of genetic linkage in somatic cells are discussed. Probable steps currently limiting the efficiency of this transfer process are also considered.