Veterinary Pathobiology presentations (MU)
Permanent URI for this collection
Items in this collection represent public presentations made by Department of Veterinary Pathobiology faculty, staff, and students, either alone or as co-authors, and which may or may not have been published in an alternate format. Items may contain more than one file type.
Browse
Recent Submissions
Item How does malaria jump from mosquitoes to humans?(2009) Beerntsen, Brenda T.Associate Professor in the Department of Veterinary Pathobiology at the University of Missouri-Columbia, Brenda Beerntsen, delivers a lecture on malaria and it's method of transmission from mosquitoes to humans.Item Darwin's germ: the life and times of E. Coli(2009) Stewart, George Cameron, 1953-Chairman of the Department of Veterinary Pathobiology in the College of Veterinary Medicine at the University of Missouri-Columbia, George C. Stewart, delivers a summary lecture on the subject of the "most misunderstood" bacteria, E. coli.Item Genetically-modified animals: powerful tools for biomedical research(2010) Critser, John Kenneth; University of Missouri (System); Missouri Life Sciences Summit (2010: University of Missouri--Kansas City)The University of Missouri houses three National Institutes of Health (NIH), National Center for Research Resources (NCRR) animal resource centers. These animal resource centers are: (1) the Mutant Mouse Regional Resource Center (MMRRC); (2) the Rat Resource and Research Center (RRRC); and the National Swine Resource and Research Center (NSRRC). These animal centers provide genetically modified animal models of human health and disease for comparative medicine research investigators. Critser will describe the goals and functions of these animal resource centers and illustrate how investigators can access these animal models, as well as the ancillary services the resource centers provide.Item The Antigen Display on Bacillus Endospore (ADOBE) System a Noninvasive Biodegradable Microparticle Display System(2010) Pritzl, C. J.; Hassett, Daniel E.; University of Missouri (System); Missouri Life Sciences Summit (2010: University of Missouri--Kansas City)The development of safe and effective vaccines and adjuvants remains an important global public health goal. The Antigen Display on Bacillus Endospore (ADOBE) system, developed at the University of Missouri's College of Veterinary Medicine, is a unique, non-replicating, microparticle-based antigen delivery platform with inherent adjuvant properties. Killed spores can be readily engineered to present single or multiple antigens to the immune system. Bioactive targeting molecules and molecular adjuvants can also be co-displayed with the immunogen on the spore surface to enhance specific innate or acquired immune responses. The combination of a strong natural adjuvant and an easily produced microparticle delivery vehicle makes ADOBE-based vaccines excellent candidates for preclinical development against a large number of human and veterinary diseases. Because virtually any molecule of interest can be covalently attached to the outer spore surface, the ADOBE method also allows for the use of spores as biodegradable solid-phase platforms for use in diagnostic tests, molecular imaging, biocatalytic reactions, and the identification, quantification, and or purification of specific compounds from a complex mixture of compounds. We are currently looking for corporate as well as academic collaborators that are interested in capitalizing on the ADOBE methodology for the development of novel biopharmaceuticals to diagnose, treat and prevent infectious and metastatic diseases.Item Targeting Tick Borne Diseases(2010) Stich, Roger W.; University of Missouri (System); Missouri Life Sciences Summit (2010: University of Missouri--Kansas City)Ticks transmit the majority of vector-borne diseases of human beings in the USA and of domestic animals worldwide. Among these, tick-borne rickettsial pathogens cause at least four important tick-borne zoonoses in the USA, and two of the five major vector- borne diseases of cattle worldwide. Notably, five of the aforementioned zoonotic and bovine diseases are endemic to Missouri. Tick-borne diseases of humans are zoonotic, and dogs are also naturally exposed to most of the etiologic agents of such maladies, suggesting potential roles of canine sentinels, reservoirs and models for tick-borne zoonoses. Our group utilizes canine ehrlichiosis (Ehrlichia canis and E. chaffeensis) and bovine anaplasmosis (Anaplasma marginale) models to better understand mechanisms of rickettsial infection of both acarine and mammalian hosts. Ticks used for these projects include Rhipicephalus sanguineus, Dermacentor variabilis, D. andersoni, Amblyomma americanum, A. maculatum and Ixodes scapularis. Projects currently underway include mechanisms responsible for rickettsial manipulation of host cell actin, and strategies that could lead to interference with tick acquisition and transmission of infections. In addition to the infectious cycles of these agents, we are also interested in pathogen interactions with the mammalian host, including the immunology and pathology of anaplasmosis and ehrlichiosis. These studies are expected to lead to better understanding of immune responses associated with different phases of ehrlichiosis, influence of vector feeding on biological and clinical outcomes of infection, immunoprophylaxis, and risk factors for exacerbation of clinical disease. The University of Missouri provides an optimal environment for this work, because i) MU has Veterinary, Medical and Agricultural colleges on the same campus; ii) MU has outstanding nucleic acid, proteomics, flow cytomety and microscopy (both fluorescence and electron) core facilities; iii) almost every tick-borne disease enzootic to the USA is in Missouri, thus allowing local access to diagnostic specimens from naturally infected hosts; iv) MU has established graduate programs in infectious disease research, pathobiology and comparative medicine; v) MU has BSL2 facilities to investigate tick-borne infections of dogs and cattle, which will soon be expanded with construction of a new Animal Resource Center; and vi) MU is home to the Missouri Regional Biocontainment Laboratory, for which an expansion of facilities is anticipated for investigation of tick-transmission of zoonotic BSL3 agents among dogs (e.g., Rickettsia rickettsii, Coxiella burnetii and Francisella tularensis). Our current capabilities center on large animal transmission, infection and disease models for anaplasmosis and ehrlichiosis. Mouse, guinea pig and rabbit models are also possible for certain tick and pathogen species. Technical skills include tick infestation of dogs and cattle, qualitative and quantitative PCR assay development and implementation, monitoring of clinical and hematologic parameters, and characterization of protective and pathogenic mechanisms with immunological and molecular methods. We are interested in opportunities to test new products designed to interfere with tick-pathogen-host interactions, and opportunities to investigate novel approaches for diagnosis or alleviation of ehrlichiosis and anaplasmosis.