2012 Health Sciences Research Day (MU)
Permanent URI for this collection
Items in this collection are the posters presented at the 2012 Health Sciences Research Day held at the University of Missouri-Columbia.
Browse
Recent Submissions
Item Self-reported symptoms and managment by midwestern breast cancer survivors(2012) Finn, Sharon M.; Gillilan, Allison L.; Krause, Madison R.; Armer, Nathan C.; Wanchai, Ausanee; Stewart, Bob R.; Armer, Jane M.; Health Sciences Research Day (2012 : University of Missouri)Lymphedema (LE) is a life-long potential consequence of breast cancer treatment that may affect quality of life of breast cancer survivors in long-term survivorship. Previous studies reported that about 2 million women living with breast cancer are at a lifetime risk for LE development. Information from self-reported lymphedema symptoms and its management will provide potential early detection and intervention to manage LE. The purposes of this study were: To report the frequency of occurrence of commonly self- reported LE symptoms following breast cancer diagnosis and treatment. To find the most commonly reported self-management actions taken for the five LE symptoms.Item Neural Stem Cells in Primary Central Nervous System Lymphoma(2012) Campbell, Jack; Miller, Douglas C.; Cundiff, Diane; Feng, Qi; Litofsky, N. Scott (Norman Scott), 1959-; Health Sciences Research Day (2012 : University of Missouri)The initial intent of this study was to examine the origins of Primary Central Nervous System Lymphoma (PCNSL), a neoplasm whose oncogenesisin immunocompetentpatients is incompletely understood. With growing information regarding the remarkable plasticity of neural stem cells, and establishment of relationships between hematopoietic and neural stem cells, we hypothesized that PCNSL arises from neural stem/progenitor cells rather than lymphocyte precursors from elsewhere in the body. Markers of neural stem cells were chosen for immunohistochemical(IHC) staining of 5 PCNSL cases and all cases contained Sox2 positive cells, whereas 8 of 9 non-CNS B cell lymphomas so stained had no positive cells. Double-staining with Sox2 and CD20, a B-cell marker, showed no co-localization of Sox2 and CD20, and no CD20-positive tumor cells had Sox2 immunopositivity. Staining of 5 metastatic carcinomas and 1 metastatic melanoma revealed a similar pattern of immunopositivityboth regarding sox2 expression and subsequent double-staining with low molecular weight cytokeratins. These findings suggest that neural stem cells are enriched in PCNSL as a reaction rather than as a source of the tumors and that sox2 expression is indicative of a neural progenitor/stem cell response to non-neural neoplasms. It follows that not all stem cell marker-positive cells in a tumor are tumor stem cells. Further understanding of the reactive response of neural stem cells is needed for understanding of neural neoplasm pathology. The presence of these findings in diverse central nervous system neoplasms and manipulation of the observation for therapeutic benefit have yet to be explored.Item Erythromycin before endoscopy in upper GI bleeding : a meta-analysis of randomized controlled trials(2012) Theivanayagam, Shoba; Lim, Roxanne G.; Cobell, William J.; Gowda, Jayashree T.; Matteson, Michelle L.; Choudhary, Abhishek; Bechtold, Matthew L.; Health Sciences Research Day (2012 : University of Missouri)Upper gastrointestinal bleeding (UGIB) is a common medical emergency that accounts for numerous hospital admissions each year. Given its significant morbidity and mortality, urgent endoscopy with adequate gastric mucosal visualization is imperative for identification and treatment of bleeding lesions. Various studies have been done evaluating the effectiveness of erythromycin infusion prior to endoscopy to improve visibility and therapeutic potential of endoscopy; however, the results have been controversial. To evaluate further, we performed a meta-analysis comparing the efficacy of erythromycin infusion before endoscopy in acute UGIB.Item Upper GI bleeding with myocardial infarction : evaluation of safety for endoscopy(2012) Lim, Roxanne G.; Cobell, William J.; Theivanayagam, Shoba; Kilgore, Todd W.; Matteson, Michelle L.; Puli, Srinivas; Bechtold, Matthew L.; Health Sciences Research Day (2012 : University of Missouri)Upper gastrointestinal bleeding (UGIB) in the setting of acute myocardial infarction (MI) is a complex medical condition with substantial morbidity and mortality. The anemia due to the UGIB may exacerbate the MI or the anticoagulation for the MI may contribute to UGIB. In addition, both have many significant complications. Several studies have been performed in studying the safety of EGD after MI; however, these studies vary in definitions and results. This study evaluated the safety and effect of EGD in patients with acute MI in a tertiary-care center.Item Systemic hemangiomatosis with a deletion in the KRIT1 gene : an unusual manifestation of cerebral cavernous malformation(2012) Odum, Brian R.; Wen, Fang; Anthony, Douglas C.; Health Sciences Research Day (2012 : University of Missouri)Cavernous hemangiomas are common hamartomatous vascular proliferations often seen as incidental solitary lesions. Rarely they occur as multifocal lesions, often in characteristic locations as part of a hereditary syndrome. We report a case of systemic hemangiomatosis with multifocal involvement of the CNS, spleen, liver, adrenal, and axial skeleton recognized at autopsy. Systemic hemangiomatosis involving solid organs, the central nervous system, and bone has been described in case reports, but this collection of findings is exceedingly rare. We hypothesized that the anomalies noted at autopsy in this case might represent sporadic cerebral cavernous malformation (CCM1), specifically de novo mutation of KRIT1.