Pathology and Anatomical Sciences publications and presentations (MU)
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Items in this collection are publications and presentations made by Department of Pathology and Anatomical Sciences faculty, staff, and students, either alone or as co-authors, and which may or may not have been published in an alternate format. Items may contain more than one file type.
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Item Heterotopic gray matter in white matter in a 62 year old(2013) Campbell, Jack; Sramek, Brett; Miller, Douglas C.; Health Sciences Research Day (2013 : University of Missouri)"Heterotopia" describes normal cells in an abnormal location, and in the context of neurobiology, usually refers to neurons or gray matter in the leptomeninges or in periventricular or subcortical white matter, ("Gray Matter Heterotopia"). While once thought to be quite rare, the widespread MRI availability allowed increased recognition of these malformations. Clinically, gray matter heterotopias usually manifest as seizures in the first and second decades of life and may have associated motor and cognitive developmental disturbances. We report a patient with no known prior neurologic history, who developed seizures at the age of 62, which were subsequently determined to be from a subcortical gray matter heterotopia. The patient presented to an outside hospital with episodic confusion thought to represent partial seizures, and also numbness in her left foot, leg, and arm. MRI revealed a thickened corpus callosum and abnormal signal extending into the right cingulate gyrus white matter with an infiltrative appearance suggestive of a glioma or gliomatosis. Stereotactic biopsy demonstrated white matter containing irregular islands of synaptophysin-immunopositive gray matter within which there were large dysplastic neurons. This established a diagnosis of ectopic gray matter in the subcortical white matter. To our knowledge, this is the oldest age at which a person with this congenital condition has experienced onset of related symptoms.Item Block 3 Histology Laboratory Exam 2004: Endocrine organs, female reproductive system, male reproductive system(William J. Krause, 2004) Krause, William J., II, 1942-Item Block 1 Histology Laboratory Exam 2003: Basic Tissues(William J. Krause, 2003) Krause, William J., II, 1942-Histology examination with slides.Item Block 2 Histology Laboratory Exam 2003: Cardiovascular, system, respiratory system, urinary system, digestive system(William J. Krause, 2003) Krause, William J., II, 1942-Histology examination with slides.Item Krause's Self Examination Atlas for the Histology Laboratory : Organs/Systems(William J. Krause, 2015) Krause, William J., II, 1942-Use of a Histology Atlas presented in an examination format can be utilized as a teaching tool for the Histology Laboratory and provides a means to aid novice students sharpen their identification skills and understanding of this discipline in preparation for practical laboratory examinations. The following questions are designed to aid students sharpen their identification skills when examining cells, tissues, and organs using the light microscope. On occasion, pertinent electron micrographs [both transmission and scanning electron micrographs] have been included to ensure a thorough presentation of microscopic structure. Several repeat questions utilizing both paraffin and plastic embedded materials have been presented as subtle differences in tissue appearance for each preparation do exist. Different types of questions [how the question is worded] are asked not only to aid the beginning student with refining identification skills but also to sharpen their reasoning and critical thinking skills when evaluating and interpreting a histological specimen. Of these – the simple question – identify the tissue/organ presented- then- justify the conclusion- is by far the most important. In this format the student should provide two or three morphological features that characterize the tissue/ organ in question and are unique to the tissue/ organ under consideration. When this format is utilized it is essential that the student be required to provide concrete reasons to substantiate the rational for the choice made with regard to each identification. The Histology Atlas was designed to follow a previous experience, either a traditional laboratory experience or a similar laboratory experience presented in an online format. Answers to the questions asked and the structures to be identified by labels are presented at the end of the atlas. Most histological preparations selected for this Histology Atlas can be found and examined further at: http://web.missouri.edu/~krausew by viewing the appropriate tutorial housed at this site. The following pre-examination exercise was designed in an attempt to help fellow students of Histology everywhere.
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