Department of Pathology Publications (UMKC)

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https://hdl.handle.net/10355/15143

Items in this collection are the scholarly output of the Department of Pathology faculty, staff, and students, either alone or as co-authors, and which may or may not have been published in an alternate format.

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Giant atypical carcinoid of the liver with vascular metastases and local sinusoidal invasion: a case report
(2007-07-12) Lingamfelter, Daniel; Hoffman, Laura; Verma, Amit; DePond, William; Lankachandra, Kamani
Abstract We present the case of a 46 year old woman with a giant, 23-centimeter, atypical carcinoid of the liver. A primary site for this neoplasm could not be identified despite multiple radiographic imaging studies, including a somatostatin scan, and a thorough inspection of the bowel during surgical resection of the lesion. Histologically, the tumor displayed mild cytologic atypia, abundant necrosis, and intravascular metastases, the last feature of which was identified by immunohistochemical markers for chromogranin and synaptophysin. Also described is the unusual sinusoidal infiltration, or "spillage," of tumor cells into the surrounding liver parenchyma, a feature that has not been described as far as we are aware but may suggest an aggressive clinical course. Even though an exact definition of atypia for these lesions apparently does not exist at this point, the multiple atypical features in this case strongly suggest the diagnosis of atypical carcinoid of the liver, thus far an altogether rare and vaguely reported entity. As more cases arise in the medical literature, it may be worthwhile to establish a set of guidelines to define atypical hepatic carcinoids and other gastrointestinal carcinoids, although survivorship data thus far indicates no significant difference in the prognosis between typical versus atypical variants.

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