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Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)
The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, ...
Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
(2015-08-04)
The objective of this study was to develop a clear, aqueous drug loaded
nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic
drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone ...
Part I: Effect of Nanomicelle Size on Trans-scleral Permeability of Dexamethasone and Part II: Strategies to Minimize Octreotide Acylation during Sustained Release from Biodegradable Polymers
(2015-06-19)
Our primary aim was to determine the effect of nanomicelle size on dexamethasone (DEX) transport across the sclera. Nanomicelles of various sizes were developed and characterized.
Low molecular weight diblock co-polymers, ...
Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)
Pentablock (PB) copolymers have been successfully synthesized for long term delivery in
the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA
approved biodegradable polymer such as ...
Prodrug Approach to Improve Oral and Brain Absorption of HIV Protease Inhibitor, Lopinavir
(2014)
The main objective of this project is to develop prodrug strategies to circumvent efflux
pumps such as P-glycoprotein (P-gp) and multidrug resistance associated proteins (MRPs),
thereby enhancing oral and brain absorption ...
Stereoisomeric Prodrugs to Improve Ocular And Oral Absorption of Prednisolone
(2015-08-11)
The primary objective of this project is to develop stereoisomeric prodrugs such as Lvaline-
D-valine-prednisolone (LDP) and D-valine-L-valine-prednisolone (DLP) to improve
ocular and oral absorption of prednisolone. ...