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Estradiol regulates multiple tetrodotoxin-sensitive sodium currents in gonadotropin releasing hormone neurons: implications for cellular regulation of reproduction
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The gonadotropin releasing hormone (GnRH) neuron is the pivotal control center in a tightly regulated reproductive axis. Estradiol typically has a ...
Three mutations that cause fifferent [i.e. different] forms of canine neuronal ceroid lipofuscinosis
(University of Missouri--Columbia, 2006)
Neuronal ceroid-lipofuscinosis (NCL), also known as Battens disease, is really a group of inherited neurodegenerative diseases. A common feature of the ceroid lipofuscinoses is the deposition of autofluorescent cytoplasmic ...
Characterization of the humoral immune response to a commercial staphylococcus aureus mastitis vaccine
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The objective of this thesis was to test the hypothesis that a commercial vaccine for bovine S. aureus mastitis fails to induce a humoral immune response ...
In vitro evaluation of veterinary and human suture anchors in metaphyseal bone of the canine tibia
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Suture anchors, also called bone or tissue anchors, provide orthopedic surgeons a mechanism for secure fixation of soft tissues to bone. A human system ...
Role of the intermediate-conductance Ca²⁺-activated K⁺ channel (K[ca]3.1) in coronary smooth muscle cell phenotypic modulation
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Smooth muscle cell phenotypic modulation is characterized by suppression of smooth muscle specific marker gene expression, migration, and proliferation ...
Mechanisms regulating skeletal muscle satellite cell cycle progression
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Skeletal muscle fibers are multinucleated with each myonucleus capable of governing a finite cytoplasmic volume. In healthy skeletal muscle, myonuclear ...
Characterization of the alignment of the canine pelvic limb
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Angular limb deformities are common place in the canine. Until recently, repair of deformities was based upon crude radiographic measures of bone ...
Fgf2-stimulated proliferation is lower in muscle precursor cells from old rats
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In aged skeletal muscle, impairments in the regrowth and regeneration may be explained by a decreased responsiveness of muscle precursor cells (MPCs), ...
A missense mutation in Atf2 in standard poodles with fatal neonatal encephalopathy
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Neonatal encephalopathy with seizures (NEWS) is a previously undescribed autosomal recessive disease in Standard Poodles. Affected puppies are small ...
Paradoxical dysuria among dogs with degenerative lumbosacral stenosis
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Degenerative lumbosacral stenosis (DLSS) is a multifactorial condition affecting predominantly large breed dogs. The combination of stenosis and ...
Metabolic responses to a westernized diet administered to rats selectively bred for high and low amounts of voluntary exercise
(University of Missouri--Columbia, 2015)
Introduction: The purpose of my study was to determine if rats with varying levels of inherent motivation to voluntarily run in wheels, when given no access to voluntary running wheels, would retain any protective affects ...
The role and mechanism of brain derived neurotrophic factor in autonomic and cardiovascular control in the nucleus tractus solitarii
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The brainstem nucleus tractus solitarii (nTS) is the primary site at which cardiovascular afferent input is relayed to central autonomic pathways and ...
New strategies in canine corneal wound healing for the veterinary ophthalmic patient
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Canine corneal fibrosis is a significant clinical problem in veterinary ophthalmology. Corneal wound healing following injury or infection often results ...
The role and mechanisms of hexokinase-2-mediated protection against cardiac cell death and disease
(University of Missouri--Columbia, 2013)
Numerous cancer studies demonstrate that transformed cells exhibit both increased glucose metabolism and an increased propensity to survive in the face of stressful stimuli. These studies overwhelmingly correlate with ...
Physiological responses of adipose tissue to different models of physical activity and inactivity
(University of Missouri--Columbia, 2013)
Childhood is a critical time of growth, and decisions made during this time lead to positive and negative health consequences, specifically pertaining to adiposity. There is convincing evidence that children who are ...
Noonan Syndrome with multiple lentigines : insights into hypertrophy and hypercontractility
(University of Missouri--Columbia, 2015)
Noonan Syndrome with Multiple Lentigines (NSML) is a rare genetic disease resulting in a phenotype with specific features, most importantly left ventricular cardiac hypertrophy. The majority of NSML cases result from ...
Effects of voluntary running on brain mitochondrial biogenesis in rats selectively bred to run high and low nightly distances
(University of Missouri--Columbia, 2015)
It is known that brain mitochondrial dysfunction is strongly associated with the advent of neurodegenerative diseases and that exercise is an important non-pharmaceutical method of maintaining brain mitochondrial health. ...
Gold nanoparticle-biomolecule conjugates : synthesis, properties, cellular interactions and cytotoxicity studies
(University of Missouri--Columbia, 2008)
This research focuses on conjugation of two major biomolecules i.e., Bombesin and Annexin V, to AuNps and studying their target specificity. The target specificity of AuNps coated with Bombesin, a GRP receptor specific ...
Immunomodulators in feline asthma
(University of Missouri--Columbia, 2010)
Experimental asthma was induced in 10 cats using Bermuda grass allergen (BGA) and cats were randomly selected to receive either feG (1 mg/kg, PO) or saline for 2 weeks, followed by a 2 week washout period before receiving ...
Upregulation of COX-2 protein expression in porcine macula densa with L-NAME treatment
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] COX-2 inhibitors are newly developed drugs which are widely used for controlling pain and inflammation. Blocking this enzyme impedes the production ...