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Effect of colostral administration practices on serum immunoglobulin concentration in dairy calves
(University of Missouri--Columbia, 2008)
Despite the accumulated understanding of the factors which affect passive transfer of colostral immunoglobulins and its recognized importance in dairy calves, approximately 35-40 % of US dairy calves have inadequate passive ...
The type I IFN of Bos taurus
(University of Missouri--Columbia, 2008)
The Type I interferons (IFN) have major roles in the innate immune response to viruses, a function that is believed to have led to rapid expansion in the number and complexity of their genes. IFNT, which is a unique Type ...
Large scale CpG island methylation profiling of small B cell lymphoma
(University of Missouri--Columbia, 2008)
DNA methylation plays a significant role in cellular differentiation and biologic activity through silencing of gene expression and also appears to be a factor in the progression of different types of cancer, including ...
The role of the innate immune system in microbially induced intestinal inflammation and neoplasia
(University of Missouri--Columbia, 2013)
Inflammatory bowel disease (IBD) is one of the most common immune-mediated diseases in the United States costing the average patient tens of thousands of dollars annually, and greatly diminishing quality-of-life. While ...
Identification of factors that promote satellite cell motilityIdentification of factors that promote satellite cell motility
(University of Missouri--Columbia, 2014)
An important but poorly understood aspect of stem cell-mediated skeletal muscle regeneration is stem cell recruitment and motility within the damaged tissue; a failure to spread after therapeutic engraftment is also a key ...
The utility and limitations of the TRAMP model system for studying the effects of hedgehog targeted therapy in prostate cancer
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Advanced prostate cancer has a very poor prognosis and no curative therapies. Understanding of the hedgehog (Hh) signaling pathway, a potential target ...
Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR required for initiation of autoimmune neuroinflammation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Posttranscriptional gene regulation is a critical mechanism of controlling the gene expression. The RNA binding-proteins (RBPs) mediate RNA splicing, ...
Characterizing the progression of disease associated with human meniscal pathology
(University of Missouri--Columbia, 2013)
Meniscal fibrocartilaginous structures are subject to numerous stresses when performing its necessary functions to maintain intra-articular homeostasis. Pathological events causing a loss of tissue integrity will result ...
Molecular genetic studies in canine inherited diseases including neonatal cerebellar ataxia, degenerative myelopathy and multiple system degeneration
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The inherited diseases of the domestic dog mimic a wide spectrum of common human disorders. By identifying the genes that harbor the mutations underlying ...
Defining the therapeutic window in spinal muscular atrophy :time points study
(University of Missouri--Columbia, 2013)
Spinal muscular atrophy (SMA) is caused by the loss of a single gene, survival motor neuron-1 (SMN1), which results in the rapid deterioration of motor neuron integrity and function, most often leading to infantile death. ...
Kinetics of monocytotropic Ehrlichia infections, new insights from large animal models
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ehrlichia are tick-borne, obligate intracellular prokaryotic parasites found in host-derived parasitophorous vacuoles. The monocytotropic Erlichia ...
Development of a nanomaterial-tissue patch for vascular and cardiac reconstruction
(University of Missouri--Columbia, 2014)
Murine theiloviruses : characterization and pathogenesis of enteric and disseminated disease
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Rat theilovirus (RTV), a member of the Theilovirus (ThV) species and closely related to Theiler's murine encephalomyelitis virus (TMEV), is a prevalent ...
Ecomorphological implications of primate dietary variability: an experimental model
(University of Missouri--Columbia, 2013)
The evolution and function of the mammalian skull and feeding apparatus is intimately related to the mechanical demands imposed by food items. The diets of wild species are often seasonal and thus individuals may experience ...
Development of biological hip resurfacing in dogs
(University of Missouri--Columbia, 2012)
Total joint replacement remains an excellent treatment for patients with debilitating joint degeneration. However, joint replacement using non-absorbable prostheses can deteriorate and become loose over time. A superior ...
Universal blood : the life stream all four one and one for all : an enzymatic methodology creating a universal blood supply
(University of Missouri--Columbia, 2012)
α-NAGA (α-N-acetylgalactosaminidase) is an exoglycosidase that cleaves a specific carbohydrate, terminal linked 1-3 α-N-acetylgalactosamine, from the A antigen. The enzymatic hydrolysis creates the H antigen. This modification ...
Mapping the language-specific cerebrocerebellar network of the human brain through diffusion tensor imaging
(University of Missouri--Columbia, 2015)
Language was arguably a key influence in the evolution of the human brain and the evolution of this behavior in humans was likely associated with gross morphological changes and novel neural networks. My dissertation looked ...
Examine the role of minor splicing pathway in spinal muscular atrophy
(University of Missouri--Columbia, 2014)
Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder mainly caused by deletions or mutations of one gene, Survival Motor Neuron (SMN). SMN is crucial in splicing processes for proper gene expression. Previous ...
DLC1 as a comparative epigenetic biomarker for radiotherapy of Non-Hodgkin's lymphoma
(University of Missouri--Columbia, 2007)
The American Cancer Society estimates that 58,870 people were diagnosed with non-Hodgkin's lymphoma (NHL) in 2006, and 18,840 people died of the disease. Recent investigation of epigenetic gene regulation has identified ...
Characterization of interactions involving the polycystic kidney disease-causing proteins: SamCystin and Bicc1
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Rodent models, including the Han:SPRD-Cy rat and the jcpk mouse, have been useful for identifying and characterizing genes that cause Polycystic Kidney ...