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Patients with venous thromboembolism have higher prevalence of obstructive sleep apnea than the general population
(University of Missouri--Columbia, 2010)
Study Objectives: Obstructive sleep apnea (OSA) has been linked to a large number of cardiovascular diseases. However, the link between OSA and venous thromboembolic events (VTE) remains unclear. We sought to study the ...
Development of post-traumatic osteoarthritis models to evaluate the effects of impact injury on joint health for clinical disease treatment and prevention
(University of Missouri--Columbia, 2013)
Osteoarthritis is one of the most common, debilitating, musculoskeletal diseases in the world. Currently, there is no cure. It is well-known that a traumatic, joint injury increases the risk of developing post-traumatic ...
Aberrant DNA methylationof RUN domain containing 3B in lymphoid malignancies
(University of Missouri--Columbia, 2013)
Heritable changes to DNA conformation can have significant impacts on gene expression without altering the DNA sequence. The RUN domain containing 3B gene (RUNDC3B) has been shown to be differentially expressed in cancer ...
3D analysis of hip joint mobility and the evolution of locomotor abilities in miocene hominoids
(University of Missouri--Columbia, 2013)
The emergence of extant ape-like locomotor behaviors has become a defining issue in reconstructing ape evolution. Suspensory positional behaviors, such as antipronograde bridging, climbing, clambering and transfer, distinguish ...
Grasping pressures and phalangeal curvature in primates : an experimental in vivo approach
(University of Missouri--Columbia, 2015)
Phalangeal curvature is often used to infer arboreal locomotion in fossil primate species. This is based off an hypothesis of plasticity linked to a loading model that suggests that, when flexed during grasping, a curved ...
Archosaur hip joint anatomy and its significance in body size and locomotor evolution
(University of Missouri--Columbia, 2015)
Archosaurs (crocodylians, birds and their extinct relatives) underwent numerous evolutionary transitions in limb morphology and body size, reflecting a diverse suite of postural and behavioral adaptations. Among archosaurs, ...
Computational modeling, ontogeny, and biomechanics of cranial forces in Alligator mississippiensis
(University of Missouri--Columbia, 2015)
3D computational modeling offers researchers tools to investigate forces in the skull during feeding and other behaviors. The American alligator and other crocodylians generate the highest bite forces among vertebrates, ...
Global DNA methylation and gene expression analysis in pre-B cell acute lymphoblastic leukemia
(University of Missouri--Columbia, 2015)
Acute lymphoblastic leukemia (ALL) is a hematological cancer associated with precursor B-cells and is the most common cancer diagnosed in children under the age of 15. Our complete understanding of all mechanisms responsible ...
Deregulation of the notch signaling pathway N B-cell chronic lymphocytic leukemia
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] B-cell Chronic Lymphocytic Leukemia (B-CLL) is the most common hematological malignancy in United States[1], characterized by CD5+ B-lymphocytes in ...
Administration of apocynin in drinking water ameliorates transient cerebral ischemia-induced brain damage and behavioral deficits in mice
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Acute ischemic stroke is the third leading cause of death in developed countries and the most frequent cause of permanent disability in adults worldwide. ...
Mechanism-based inhibition of matrix metalloproteinase-9 provides neuroprotection in a mouse model of traumatic brain injury
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Traumatic brain injury (TBI) is a leading cause of death and disability in the U.S. Following an initial mechanical impact, TBI progresses to a secondary ...
Genetic and microbiota-mediated phenotype variability in the min mouse model of human colorectal cancer
(University of Missouri--Columbia, 2019)
Complex diseases develop as a result of genetic predisposition and environmental factors that determine individual risk. Environmental factors such as geographical location, diet, and lifestyle choices shape the gut ...
Reflux, aspiration and respiratory disease in dogs : clinical consideration and advances in aerodigestive diagnostics
(University of Missouri--Columbia, 2019)
The aspiration of gastric contents into the respiratory tract has been associated with the development and progression of multiple respiratory diseases in humans. In veterinary medicine the term "aspiration" is considered ...
Dimorphism and integration in the pelves of anthropoid primates
(University of Missouri--Columbia, 2016)
The link between obstetric demand (natural selection for birth) and pelvic morphology in anthropoids has remained ambiguous for the past century. Though it is assumed that the dramatic sexual dimorphism seen in modern human ...
Bivalent peptide-based radioconjugates for prostate cancer imaging and potential therapy
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Introduction: Despite decades of research, prostate cancer remains an important disease, with 1 out of 7 men diagnosed within his lifetime. In 2017, ...
RNA-sequencing analysis in B-cell acute lymphoblastic leukemia reveals aberrant gene expression and splicing alterations
(University of Missouri--Columbia, 2017)
Background: B-cell acute lymphoblastic leukemia (B-ALL) is a neoplasm of immature lymphoid progenitors and is the leading cause of cancer-related death in children. The majority of B-ALL cases are characterized by recurring ...
Advancements in the understanding of staphylococcal mastitis through the use of molecular tools
(University of Missouri--Columbia, 2017)
The objectives of this work were: 1) to complete a whole genome sequence of a Staphylococcus chromogenes isolate that is known to persist in the mammary gland of a cow, 2) to define a genetic target that could easily and ...
Biological responses of ligament and tendon graft-derived fibroblasts to clinical levels of cyclic strain
(University of Missouri--Columbia, 2020)
Anterior Cruciate Ligament (ACL) is one of the major ligaments in the knee. ACL injury is the partial or complete tear of the ACL usually as a consequence of a traumatic sports related injury. ACL injury commonly affects ...
The influence of host genetics, virome, and gut microbiota transfer methods in mouse model reproducibility
(University of Missouri--Columbia, 2021)
Gut microbiome (GM), the complex community that combines all bacteria, viruses, protozoa, and fungi located in the gut of human or animal, plays a significant role in host health and disease. Animal model are widely used ...
Function and evolution of the crocodyliform feeding apparatus
(University of Missouri--Columbia, 2021)
The evolution of crocodylians from their suchian ancestors represents one of the great transformations in vertebrate evolution. Modern crocodylians have flat skulls and generate high forces during feeding, but crocodylian ...