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Discovery and Delivery of Peptide-Based Immune Checkpoint Inhibitors Targeting Pd-L1 for Cancer Immunotherapy
(2022)
The objective of this dissertation is to develop peptide-based immune checkpoint inhibitors that block the interaction between programmed cell death ligand-1 (PD-L1) and its receptor programmed cell death protein 1 (PD-1) ...
Development of Amino Acid-Modified Drug Delivery Systems for RNA Delivery in Cancer Therapeutics
(2022)
The primary objective of my research is to develop polymer and lipid-based nanoparticles to effectively deliver therapeutic RNAs for life-threatening diseases. Small interfering RNAs (siRNAs) and messenger RNAs (mRNAs) are ...
Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
(2022)
In the last few decades cancer immunotherapy has emerged as a standard pillar of cancer treatment. Immune checkpoint inhibitors that are currently available target the adaptive immune system, generating T-cell antitumor ...