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Atomic-scale studies of chemical and transport processes relevant to propellant combustion
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Density functional theory (DFT) and correlated molecular orbital electronic structure calculations were used to study the Al + CO2 [subscript arrow] ...
Diverse applications of covalent cross-links in duplex DNA: From anti-cancer drugs to the detection of disease-relevant single nucleotide polymorphisms to the synthesis of well-defined substrates for the study of novel DNA repair processes
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Abasic (Ap) sites are a common form of DNA lesion that occur endogenously 50,000-200,000 per cell per day in mammals. The alkylation of the guanine and ...
Solvatochromic pyrogallarenes and pyrogallarene crystals
(University of Missouri--Columbia, 2018)
Pyrogallarenes have the ability to self-assemble into a variety of structures. Crystal forms ranging from bilayers to dimers and hexamers have been isolated. One unique cocrystal, PgC[subscript 3]-(CH[subscript 3])[subscript ...
Studies and synthetic methodology of Nampt inhibition
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The purpose of this research is to study and synthesize an array of a highly potent pharmaceuticals that can selectively cause apoptosis in various ...
Technetium and rhenium (I and V) complexes for radiopharmaceutical applications
(University of Missouri--Columbia, 2016)
Technetium and rhenium have radioactive isotopes that are clinically useful for diagnostic (Tc-99m) or therapeutic (Re-186/188) purposes. This makes them attractive candidates for incorporation into pharmaceuticals. One ...
The use of polyhedral borane derivatives as molecular electronic scaffolds
(University of Missouri--Columbia, 2016)
When functionalized, the highly symmetrical, three-dimensional aromatic cluster, closo - dodecahydrododecaborate, or dodecaborate, has a two, one - electron oxidation pathway available to it. The framework of dodecaborate ...
Finite element analysis for the insertion process of the press-fitted total hip arthroplasty
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] There are more than 300,000 total hip arthroplasty (THA) surgeries performed every year in the United States. Press-fitted artificial hip joints are ...
The synthesis of a fluorescent bioconjugation agent
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Bioconjugation linkers are used covalently link two molecules, where at least one is a large biomolecule for uses such as tracking cellular function, ...
Crystal engineering of supramolecular complexes based on pyrogallol[4]arenes
(University of Missouri--Columbia, 2016)
Crystal engineering primarily deals with the understanding of intermolecular interactions in the context of crystal packing and thus utilizes this information for the designing and development of novel crystalline solid ...
Radionuclide production and separation techniques for radiopharmaceutical development and nuclear waste processing
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] With increasing cancer incident rates and advancements in nuclear medicine, the demand for optimizing pathways to produce radionuclides or investigating ...
Nuclear forensic applications of uranium oxide chemistry and morphology
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The entire nuclear fuel cycle is a chemistry-intensive process, from accessing the raw materials from ore, to enriching and forming the fuels, to the ...
Synthesis and reactivity of actinide phosphorano-stabilized carbene and phosphido complexes
(University of Missouri--Columbia, 2018)
Nuclear power plants have been operated in the United States for over 60 years, generating over 800 terawatt-hours of energy per year. However, there is still no reliable process to recycle the spent nuclear fuel. This ...
LC-MS/MS method development for quantification of bioactive compounds in elderberry and garlic botanicals
(University of Missouri--Columbia, 2016)
Elderberry (Sambucus nigra spp.) juice contains a variety of polyphenols mostly anthocyanins. In order to understand the variation of polyphenol levels by genotype, various elderberry juice samples were analyzed for total ...
Gold-catalyzed generation of vinylthionium ions and the development of an organocatalytic, asymmetric (4+3)-cycloaddition reaction
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] An allylic benzoate ester was prepared and used as a progenitor of vinylthionium ions for (4+3)-cycloaddition reactions. The chemistry was limited to ...
Deep ultraviolet resonance Raman spectroscopy as a tool for biomolecule analysis
(University of Missouri--Columbia, 2017)
Cholesterol is a major component of membranes, reducing their fluidity at higher concentrations. The UV Raman vibrational mode of the carbon-carbon double bond in cholesterol occurs at 1675 cm-1 is strongly resonance ...
Synthesis and photochemistry of PT (IV) hydroxo complexes
(University of Missouri--Columbia, 2015)
Global energy consumption and the production of clean renewable energy have become greater challenges. Sunlight-induced splitting of water into H2 and O2 is one of the leading strategies to achieve clean and renewable ...
Economical synthesis of carbon nanoparticles
(University of Missouri--Columbia, 2016)
One of the core values of a capitalistic market is cost efficiency which is tried and true even in cursed with discovering and developing materials as inexpensive as possible. Now, this is for a multitude of reasons but ...
Mechanistic and computational studies of ferroin, simple organic acids, and bromine oxides : elucidating the complex electrochemical dance in an oscillating reaction
(University of Missouri--Columbia, 2016)
Before the year 1950, many chemists in their 'right mind' held the archaic belief that all chemical reactions proceed strictly from reactants to products, though some could be coaxed into reverse. What we now know colloquially ...
The development of exo-affinity labeling agents, inactivators of protein tyrosine phosphatase 1B
(University of Missouri--Columbia, 2016)
The phosphorylation of a tyrosine substrate is one of the most crucial reactions that regulate numerous biological processes. The phosphorylation is controlled by protein tyrosine kinases (PTKs) and protein tyrosine ...
Fluorescent sensors for the detection of glucosamine and thiaminase
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Fluorescence chemical sensing is a highly important tool in science and industry with many applications in pharmaceutical screening, cell respiration, ...