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Analysis of factors that affect pseudotyping in retroviruses
(University of Missouri--Columbia, 2019)
Retroviral vectors can efficiently pseudotype with various envelope glycoproteins; however, the molecular mechanism of glycoprotein acquisition process is not completely understood even with their native Env proteins. ...
Mechanisms of immunity and inflammation in Brucella-induced arthritis
(University of Missouri--Columbia, 2018)
arthritis, inflammation may also be vital for pathogen restriction. This creates a paradox when identifying appropriate treatments for brucellar arthritis as administration of anti-inflammatories may increase bacterial replication in the host. Thus...
Novel protective modifiers in mouse models of spinal muscular atrophy
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by the homozygous deletion or mutation in the survival motor neuron-1 (SMN1) gene resulting in extremely low...
Labeling HIV-1 nucleic acids during infection and effect of MOV10 in HBV replication
(University of Missouri--Columbia, 2018)
Technical limitations in simultaneous microscopic visualization of RNA, DNA, and proteins of HIV have curtailed progress in this field. To address this need we have developed a microscopy approach, multiplex immunofluorescent ...
Vaccine-induced protective immunity against coxiella burnetii
(University of Missouri--Columbia, 2019)
Coxiella burnetii is an obligate intracellular Gram-negative bacterial pathogen and the causative agent of human Q fever. This disease presents acutely as a flu-like illness, although it can escalate to a chronic and often ...
Contribution of the immune system and astrocytes to spinal muscular atrophy pathology
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease and the leading genetic cause of infant mortality. SMA is caused by afunctional loss of the survival...
Protection from pneumonic plague by the induction of heme oxygenase-1
(University of Missouri--Columbia, 2018)
Yersinia pestis is the etiological agent of the disease known as plague. The pathology of this disease is characterized by organ failure due to necrosis and hyperinflammation towards the end of the disease. However, Y. ...