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Investigating the roles and functions of plasma membrane E3 ligases and MKP1 in plant immunity
(University of Missouri--Columbia, 2021)
-inducing metabolites. The work in this dissertation establishes the PM-localized E3 ligase, ATL6, as a key positive regulator of PTI, playing an important role in PTI-associated resistance and effector delivery restriction, while not impacting other canonical PTI...
Roles of dynamin-related protein network in plant immune responses and development
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] At the host-pathogen interphase, the PM's protein composition has a critical role in how plants perceive and respond to the invading pathogenic attacks. However...
HIV-1 5'UTR RNA structures: connections to infectious lifecycle and potential therapeutic applications
(University of Missouri--Columbia, 2021)
for treatment. This dissertation presents work utilizing a wide range of biochemical approaches to explore the importance of the HIV-1 5'untranslated region (5'UTR) RNA in infection and strategies utilizing this gained knowledge for screening of novel...
Structural studies of flavoprotein inhibitors and inactivators
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Flavoenzymes have a versatile capacity to catalyze a wide range of reactions, using their flavin cofactor. In this thesis, work on two flavoenzymes is presented...
Investigation of the initial steps of jasmonic acid biosynthesis and a study of differential regulation of the ribosomal association of mRNA transcripts in jasmonate-dependent wound response
(University of Missouri--Columbia, 2020)
of evidence to show that the production of JA precedes the transcription and translation of JA-induced transcripts, therefore there are likely post-translational modifications occurring that elicit activation of the pathway. Chapter II of this dissertation...
RNA structural studies : implications in HIV-1 replication and the origins of life
(University of Missouri--Columbia, 2021)
Structure and function relationships are important to understand many biological processes. Biological components are not one dimensional and their structures may drive key aspects of their function. This dissertation focuses on understanding key...
Targeted cancer radioimaging and radiotherapy and the development of tumor-avid molecules using phage display
(University of Missouri--Columbia, 2021)
Prostate cancer (PCa) is the second leading cause of cancer death in men and new biomarkers are needed to improve diagnostic and therapeutic approaches in aggressive forms of this disease. CD44v6, a splice variant of the ...
Aptamers that bind filovirus GP : a new frontier for detection and neutralization of Ebola and Marburg virus
(University of Missouri--Columbia, 2020)
Aptamers are single chained, nucleic acid-based affinity probes that bind to their targets with strong affinity and specificity. They are made through an in vitro combinatorial selection method, wherein large libraries of ...
Effects of differential and combinatorial inhibition of myostatin and activin A in the G610 murine model of osteogenesis imperfecta
(University of Missouri--Columbia, 2021)
Bone fragility, increased susceptibility to fracture, and low bone mineral density (BMD) are hallmarks of osteogenesis imperfecta (OI), a rare skeletal disorder that arises primarily from defects in the generation, quantity ...