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Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
(University of Missouri -- Kansas City, 2018)
The objective of this dissertation is to develop a protein-based siRNA
nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently
discovered that silencing the poly (rC) binding protein 2 (PCBP2) ...
Discovery and Delivery of Peptide-Based Immune Checkpoint Inhibitors Targeting Pd-L1 for Cancer Immunotherapy
(2022)
the stability and activity of a linear anti-PD-L1 peptide. The cyclic peptides demonstrated up to a 34-fold improvement in the PD-1/PD-L1 blocking activity and a 4-fold improvement in serum stability. These cyclic peptides prevent apoptosis of human CD3+ T cells...
Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
(University of Missouri -- Kansas City, 2017)
The objective of this dissertation is to discover PSMA (Prostate Specific Membrane
Antigen)-specific peptide ligands using phage display and employ peptide nucleic acid as
a complementary linker to attach chemical ...