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The Study of Initiation Systems and Formulations for the Development of a Novel Silorane Biomaterial
(2015)
There are approximately one million hip and knee replacements each year in the
United States alone and over 70% are cemented for stabilization. The number of these
replacements is expected to rise to 3.5 million per year ...
Ritonavir - A Novel Multidrug Resistance Modulator in Cancer Chemotherapy and Ocular Neovascular Diseases
(2014-08-28)
Multidrug resistance (MDR), a clinical outcome characterized by subtherapeutic
intracellular drug concentration, is one of the predominant factors limiting effective cancer
chemotherapy. Several possible mechanisms and ...
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Transporter-Targeted Prodrug Delivery to Improve Oral Bioavailability of Saquinavir
(2015-05-22)
Saquinavir (SQV) is the first antiretroviral protease inhibitor approved by Food and
Drug Administration in the United States for the treatment of HIV infection due to its
potent anti-HIV activity. However, some unfavorable ...
Effects of Selected Contaminants on the Physical, Chemical, and Geotechnical Properties of Aquifer Solid
(2014)
contaminants on the hydraulic conductivity of sand. Bulk sand samples from the Missouri River Valley aquifer— a major source of groundwater supply in the U.S. Midwest— were collected for this study. Sand samples, representing the aquifer and vadose zone...
Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to develop siRNA-based cancer therapeutics. In
chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based
therapy, as well as various siRNA delivery systems. ...
Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
(2013)
Cidofovir (CDF) has shown potential in vitro and in vivo antiviral activity against cytomegalovirus (CMV) retinitis. However, low CDF permeability due to its hydrophilic nature limits its effectiveness. Furthermore, ...
Light-activated biomacromolecules
(2013)
Biomacromolecules, mainly nucleic acids and proteins, are involved in
every cellular process and therefore their aberrant level or function is linked with
most of the diseases. Controlling these macromolecules using light ...