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Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
Development and Evaluation of Nanocarriers against Atherosclerosis
(University of Missouri--Kansas City, 2016)
The objective of this project was to develop advanced nanocarriers such as
nanographene and graphene quantum dots against atherosclerosis. Mannosylated-reduced
graphene oxide (Man-rGO) was developed as a targeted ...
Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention
(University of Missouri--Kansas City, 2016)
The objective of this dissertation is to design and optimize a nanoformulations
(nanoparticle and nanofiber) delivery system loaded with anti-HIV topical microbicides for
HIV prevention in women.
In chapters 1 and ...
Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
(University of Missouri--Kansas City, 2016)
The objective of this dissertation is to present two approaches to identify Hepatic
Stellate Cells (HSCs) targeting ligands using phage-display library biopanning and
systematic evolution of ligands by exponential ...
Novel Approaches for Targeted Delivery of Cancer Therapeutics to Nuclei of Malignant Cells
(University of Missouri--Kansas City, 2016)
The primary goal of this project is to increase specific uptake of anti-cancer therapeutics by
nuclei of cancer cells. A lot of research has been done to target therapeutics specifically across
plasma membrane of ...