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Structural inferences for reverse transcribing viruses and drug resistance
(University of Missouri--Columbia, 2019)
, and as we've seen with extensive HIV-1 studies, can be thrown into disarray through targeted drug design. The implications of this work stand to benefit the study of plant pararetroviruses and could greatly inform the study of HBV RT, which to this day has...
Vaccine-induced protective immunity against coxiella burnetii
(University of Missouri--Columbia, 2019)
Coxiella burnetii is an obligate intracellular Gram-negative bacterial pathogen and the causative agent of human Q fever. This disease presents acutely as a flu-like illness, although it can escalate to a chronic and often ...
Reparative dysfunction during muscle regeneration in Duchenne muscular dystrophy: therapeutic approaches to modulating the muscle environment and muscle stem cells
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a lethal muscular dystrophy resulting from functional loss of the dystrophin protein, a critical sub-sarcolemmal ...