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Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
(2020)
Disorders affecting the posterior segment of eyes represent a significant burden to healthcare and patients’ wellbeing. Among the back of the eye disorders, age-related macular degeneration (AMD) is one of the major ailments ...
Development of Random Triblock Copolymer Based Nanoparticulate Formulation for Sustained Release of Macromolecules/Biologics in Treatment of Posterior Segment Ocular Diseases
(University of Missouri -- Kansas City, 2018)
Random triblock copolymers (RTB) were successfully synthesized by ring opening
copolymerization method. RTB copolymers are composed of FDA approved materials such as
polyethylene glycol (PEG), glycolide (GA), lactide ...
Novel Dichloroacetate Prodrugs for Improved Targeting of Breast Cancer Chemotherapeutics
(University of Missouri -- Kansas City, 2019)
It is well documented that most cancer cells utilize aerobic glycolysis or Warburg
metabolism instead of mitochondrial oxidative phosphorylation for cell energy production.
Dichloroacetate is a synthetic small molecule ...
Establishing Metronidazole as a Novel Biomarker of CYP2A6 Activity
(University of Missouri -- Kansas City, 2018)
CYP2A6 is a polymorphically expressed enzyme with variation associated with
smoking behavior, cessation success, lung cancer risk, and differential drug exposure to
numerous medications including anti-infectious and ...
Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
(2021)
by disulfide bonds, (HA-ss-PLGA). HA is a natural ligand for CD44 receptors overexpressed on breast cancer cells. Disulfide bonds undergo rapid reduction in the presence of glutathione, present in breast cancer cells. The mixed nanomicelles contained HA...