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Theoretical and computational modeling of RNA-ligand interactions
(University of Missouri--Columbia, 2021)
analyzed by primer extension” (SHAPE) experiment, enable the quantitative detection of the relative flexibility and hence structure information of RNA structural elements. Therefore, one may incorporate the SHAPE data into RNA 3D structure prediction...
Theoretical and computational modeling of naturally and artificially modified RNA nucleotides
(University of Missouri--Columbia, 2021)
analyzed by primer extension (SHAPE) experiments. SHAPE experiments selectively modify flexible RNA nucleotides and can be processed to produce a characteristic reactivity profile for an RNA molecule that contains structural information. Incorporation...