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Determination of trace elements levels in plasma from larvae in the course of baculoviral and bacterial infections by inductively coupled plasma-mass spectrometry (ICP-MS)
(University of Missouri--Columbia, 2009)
While a number of studies have examined the effect of infections on the trace elements status of mammals, not any similar study in insects are found. In this study, we used inductively coupled plasma-mass spectrometry ...
Measurement of radionuclides in biological tissues from occupationally exposed individuals
(University of Missouri--Columbia, 2022)
may provide information on the grade of the plutonium material an individual was exposed to. The measurement of radionuclides in brain tissue is of interest to the health physics community for developing internal dosimetry models. Examining...
Lc-ms/ms method development for quantitation of nicotine in toenails as a biomaker for secondhand smoke and standard lipoprotein mimetic models
(University of Missouri--Columbia, 2021)
Passive smoke or (secondhand smoke) is defined as when a non-smoker is unintentionally exposed to a smoking environment from cigarettes, cigars, or pipes. Passive smoke can result in adverse health effects leading to heart disease, asthma attacks...
Spectroscopic studies of transmembrane helical peptides and LC-MS/MS method development and validation for PFAS quantitation
(University of Missouri--Columbia, 2022)
of widespread contaminants in the ecosystem, which may cause adverse health effects under high levels of exposure. HPLC-MS/MS is commonly used for accurate and reproducible PFAS quantitation in water systems. Triple quadrupole and q-ToF mass analyzers...
Purification and characterization of A[beta] and probing the interactions between myricetin and A[beta] using various spectroscopic methods
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Worldwide, millions of people suffer from symptoms of memory loss and confusion associated with Alzheimer's disease (AD). Mounting evidence suggests ...
Radiotracers for examining biological functions of plants and microbes
(University of Missouri--Columbia, 2021)
- the bioavailable form of iron to humans- seed content. Similar studies were completed using zinc ([superscript 65]Zn, t[subscript 1/2]= 244 d), where it was noted that the presence of the low-auxin producing and nitrogen-fixing bacteria strain, ipdC, enhanced zinc...
Fission product diffusion in ig-110 graphite
(University of Missouri--Columbia, 2022)
is at its highest level in modern history but is still severely hampered by perceptions of safety and issues involving nuclear waste and proliferation. The Fukushima disaster of 2011 and the attack on Ukraine by the Russian Federation in 2022 only served...
Investigation of the thermostability and activity of biomolecules in bio-friendly deep eutectic solvents
(University of Missouri--Columbia, 2023)
DESs in an array of biomolecule-driven purposes and illustrate the versatility and potential of these unique, environmentally responsible solvents for next-generation biotechnological and biomedical applications....
Solid, aqueous, and gaseous: functional materials and advancements to reduce pollution in three forms
(University of Missouri--Columbia, 2022)
Growing environmental concerns require new and novel materials to combat the glut of anthropogenic pollution produced. Solid waste polymer pollution chokes the planet and, concerningly, has been found to generate a new class of pollutant...
Metabolically activated heterocyclic N-oxide compounds for killing and visualizing hypoxic cancer cells
(University of Missouri--Columbia, 2009)
Tirapazamine (TPZ) is currently undergoing a variety of phase I, II, and III clinical trials for the treatment of various human cancers. TPZ derives its medicinal activity by inducing DNA damage in poorly oxygenated tumor ...
LC-MS/MS method development for quantitative analysis of cyanogenic glycosides in elderberry and lipid peroxidation products in mice
(University of Missouri--Columbia, 2021)
products in the brain and in different body organs may be an important step forward towards understanding the mechanism(s) for this (n-3) fatty acid on health and diseases. Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized...
Ab-initio and thermodynamic study of 123I-MIBG and 76Br-MBBG : choosing an effective tracer and theoretical study of the binding mechanism of 1-allyl 2-Thiourea as a functional monomer of Methyl Nitrate template
(University of Missouri--Columbia, 2023)
The study of mechanisms of reactions, how molecules bind, reaction energetics, and thermochemistry of chemical reactions is possible computationally. This is because computational methods are well able to help understand ...
Oxidative molecular layer deposition of redox-active thin-film polymers
(University of Missouri--Columbia, 2022)
Thin film materials research for a more sustainable future is growing rapidly and new techniques for depositing these films are beginning to surface. One such technique is highlight in this body of work using gaseous ...
Reactivity of lesions derived from abasic (AP) sites in DNA
(University of Missouri--Columbia, 2021)
DNA is vital to cellular function. Therefore, maintaining the integrity of the structure of DNA is of the utmost importance. Damage to the DNA is unavoidable and can be detrimental to organisms. Abasic (Ap) sites are the ...
An evaluation of the need for critically refined purification procedures in fluorescent carbon dot syntheses : the ramifications of the ubiquitous presence of reaction by-products on quenchometric and light harvesting applications
(University of Missouri--Columbia, 2021)
Fluorescent carbon dots constitute a novel and intriguing class of nanocarbons that display unique optical properties and can be purportedly generated from virtually any carbon-containing source. For example, the thermal ...
Sustainable chemical approaches to two-dimensional nanosheets and mesoporous platforms and catalysts
(University of Missouri--Columbia, 2017)
. The overall focus of this doctoral dissertation has been paid to the synthesis, controlled surface modification, and functionalization of distinct types of nanoparticles and nanocomposites through sustainable chemical approaches for environmental...
Development of radiolabeled metal chalcogenide nanoparticles for targeted adiotherapy against an infection
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Targeted radiotherapy has been demonstrated to be therapeutic against infections with doses comparable to what a patient would receive for cancer ...
Production of high specific activity rhenium-186 for radiotherapeutic applications and reformulation of a novel liquid brachytherapy agent
(University of Missouri--Columbia, 2022)
The continued development of methods for the production and separation of high specific activity (HSA) rhenium-186 (t1/2 = 90.64 h, Eb-ave = 359 keV (71 percent), 306 keV (22 percent)) would largely increase its use as a ...
Arsenic-72, 77 as a matched pair radiopharmaceutical for imaging and radiotherapy
(University of Missouri--Columbia, 2018)
Radiopharmaceuticals deliver radionuclides to specific target sites via the bifunctional chelate approach, where the radionuclides are chelated with a ligand and linked to a targeting biomolecule. They can be categorized ...
Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
(University of Missouri--Columbia, 2019)
The overexpression of certain peptide receptors on cancers cells can be exploited for the development of radiopharmaceuticals that are selectively delivered to cancer cells for diagnostic imaging or therapeutic purposes. ...