Search
Now showing items 1-20 of 85
Development of novel fluorescent sensors for targeting biologically relevant molecules
(University of Missouri--Columbia, 2023)
] macrocycle were studied using 1H-NMR, COSY, NOESY , DOSY and were found to self-assemble into 1:1 and 2:1(R2H) complexes. Various secondary guests were examined for formation of ternary complexes. These complexes were studied using 1H-NMR and fluorescence...
Alkene-oxo and alkene-alkene coupling on Pt(II)
(University of Missouri--Columbia, 2005)
Tetranuclear Pt(II) oxo-complex [(COD)4Pt4([mu]3-O)2Cl2](BF4)2 (1) (COD = 1,5- cyclooctadiene) was found to readily react with a variety of alkenes (ethylene, norbornene, propylene and cyclopentene). The most significant discovery resulted from...
Monte Carlo neutronic simulations for a new approach to parametric INAA and Mo-99 production feasibility at MURR
(University of Missouri--Columbia, 2009)
A novel approach to parametric instrumental neutron activation analysis at MURR has been established. In particular, a detailed MCNP5 steady-state model of the MURR core was developed. The model, which was based on the most recent continuous...
Applications of elemental analysis for archaeometric studies : analytical and statistical methods for understanding geochemical trends in ceramics, ochre and obsidian
(University of Missouri--Columbia, 2006)
Three areas are covered in this dissertation: elemental analysis of Caborn-Welborn ceramics, elemental analysis and geochemical characterization of ochres, and construction and implementation of a portable XRF instrument ...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
. For instance, alpha and beta particles are used for treatment of disease, while gamma and positron emissions are useful for disease detection. There are three main ways to develop a radiopharmaceutical drug; 1) through direct administration of a radionuclide, 2...
Investigation of CO2 capture systems, Lewis acid-base pairs, and oscillating reactions with electronic structure theory and kinetics-based approaches
(University of Missouri--Columbia, 2020)
reaction rate constants. Usually, a few simple applications are discussed, primarily in the area of acid-base chemistry. The topic is revisited in organic chemistry and clarified conceptually with reaction energy diagrams. To study equilibrium as a student...
Polyionic nanoclays as tailorable hybrid organic-inorganic platforms
(University of Missouri--Columbia, 2021)
We disclose the synthesis, characterization, and application of an imidazolium-based hybrid inorganic-organic layered magnesium phyllo(organo)silicate nanosheets, coined polyionic nanoclays (PINCs), as an emergent class of supported ionic liquids...
Aza-analogues of distyrylbenzene (DSB) synthesis, structures, and properties of 1,4-phenylenediamine bisimines (PDABI)
(University of Missouri--Columbia, 2006)
) as intermolecular synthons. The purpose of this study is to probe the aza-analogues of distyrilbenzene, heretofore referred to as the bisimines (Ph-C=N-Ph-N=C-Ph). In chapter 1, the design principal and synthesis of the symmetric bisimines will be presented. Chapter...
Near infrared fluorescent sensors for selective glucose recognition
(University of Missouri--Columbia, 2021)
, near IR pH probes based on cyanine fluorophores were designed and synthesized. These probes provided insight into practicality of cyaninebased near IR sensors for use in vivo and served as a starting point to achieve the ultimate goal of glucose...
Ligands for the sigma receptor and the mu-opioid receptor
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family with two subtypes: sigma-1 and sigma-2. In order to conduct structure-activity relationship studies (SAR), a series of specific 1-phenylpropyl-4-benzylpiperidine and 1-phenylpropyl-4- benzylpiperazine...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
-DOTA-Conjugate in PC-3 cell line were assessed. The biodistribution and uptake studies of [superscript 111]In-DOTA-Conjugate were performed in healthy CF-1 mice. Pharmacokinetic studies were performed in PC3 tumor-bearing SCID mice. Micro SPECT/CT imaging...
Investigation of K₀ NAA at MURR and investigation of the toenail as a biomonitor for Mg, Zn, Cu, Se and Hg
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Chapter 1: The K[subscript 0] method of neutron activation analysis (INAA) requires a stable core and neutron flux parameterization. The stability of the reactor core at MURR...
Deantiaromatization as a driving force in an electrocyclization of cyclopentadienone and the total synthesis of 1-epi-esco-pseudopteroxazole
(University of Missouri--Columbia, 2007)
with high stereoselectivity. Some evidence was uncovered to show that the process is indeed an 8 [pi] conrotatory electrocyclic ring closure. During the exploration of substituent effects in the electrocyclization, a novel coupling reaction...
Anisotropic organic materials : ferroelectric crystals and spin-polarized radicals
(University of Missouri--Columbia, 2007)
-aligned crystals because of the much higher chromophore density as compared to polymers. To deeply investigate these crystalline materials, 1,4-diphenyl-butadiene and its derivatives have now been studied. In Chapters 1 - 4, crystal packing of polymorphs of (E,E)-1...
Core-based hyperbranched polyethyleneimine coating in capillary electrophoresis
(University of Missouri--Columbia, 2009)
. , core-based hyperbranched polyethyleneimine (CHPEI) polymer utilized as either a static or dynamic coating in this study. A CHPEI-coated capillary was simply constructed in a rinsing fashion or by adding a small amount of CHPEI in a running buffer...
Synthesis and evaluation of [105]Rhodium (III) complexes of phosphine chelate systems
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] [Superscript 105]RH has attractive nuclear and chemical properties to be investigated as a nuclide for development of potential radiopharmaceuticals. ...
Synthethic pathways to multiple surface functionalization of polyhedral boranes
(University of Missouri--Columbia, 2019)
and n-propylamine as a great substitute for methylamine in the reaction for the formation of dithiol derivative from 1. A yield of 70% - 75% of the bis-(1,12-thiol)-closo-dodecaborate(2-) and 75% - 83% of bis-(1,7-thiol)-closo-dodecaborate(2...
Technetium and rhenium schiff base complexes for nuclear medicine
(University of Missouri--Columbia, 2019)
This dissertation investigates the synthesis of rhenium and technetium Schiff base complexes for potential applications in nuclear medicine. In Chapter 2, a series of mixed ligand Re(III) complexes of the form trans-[Re(PR3)2(tmf2en)]+ were prepared...
Intermolecular (4+3) cycloaddition reaction of oxidopyridinuim ions with silylated dienes, exploring the oxidation chemistry and photochemistry of cycloadducts
(University of Missouri--Columbia, 2022)
carbon was unsuccessful. Based on the proposed mechanism and the product formation, HFIP acted as the nucleophile. An extension of the aforementioned study investigated the efficacy of the (4+3) cycloadducts as reactants in a [2+2] photocycloaddition...