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Applications of elemental analysis for archaeometric studies : analytical and statistical methods for understanding geochemical trends in ceramics, ochre and obsidian
(University of Missouri--Columbia, 2006)
Three areas are covered in this dissertation: elemental analysis of Caborn-Welborn ceramics, elemental analysis and geochemical characterization of ochres, and construction and implementation of a portable XRF instrument ...
Alkene-oxo and alkene-alkene coupling on Pt(II)
(University of Missouri--Columbia, 2005)
Tetranuclear Pt(II) oxo-complex [(COD)4Pt4([mu]3-O)2Cl2](BF4)2 (1) (COD = 1,5- cyclooctadiene) was found to readily react with a variety of alkenes (ethylene, norbornene, propylene and cyclopentene). The most significant discovery resulted from...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
and therapy. Gold(III) chemistry, however, creates pitfalls to the applicability of these isotopes. Gold(III) has the problem of oxidizing donor ligands, or being reduced to Au(0). The benefit of using bis-thiosemicarbazides based chelates...
Development of novel fluorescent sensors for targeting biologically relevant molecules
(University of Missouri--Columbia, 2023)
constructs. Next, several sensors were developed for both inhibition and detection of thiaminase enzyme. The two novel fluorescent irreversible inhibitors were designed based on sulforhodamine and the sensor for measuring thiaminase activity was developed...
Polyionic nanoclays as tailorable hybrid organic-inorganic platforms
(University of Missouri--Columbia, 2021)
We disclose the synthesis, characterization, and application of an imidazolium-based hybrid inorganic-organic layered magnesium phyllo(organo)silicate nanosheets, coined polyionic nanoclays (PINCs), as an emergent class of supported ionic liquids...
Core-based hyperbranched polyethyleneimine coating in capillary electrophoresis
(University of Missouri--Columbia, 2009)
. , core-based hyperbranched polyethyleneimine (CHPEI) polymer utilized as either a static or dynamic coating in this study. A CHPEI-coated capillary was simply constructed in a rinsing fashion or by adding a small amount of CHPEI in a running buffer...
Monte Carlo neutronic simulations for a new approach to parametric INAA and Mo-99 production feasibility at MURR
(University of Missouri--Columbia, 2009)
A novel approach to parametric instrumental neutron activation analysis at MURR has been established. In particular, a detailed MCNP5 steady-state model of the MURR core was developed. The model, which was based on the most recent continuous...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bombesin-like peptides bind to gastrin-releasing peptide receptor subtype 2 (BB2) with significantly high binding affinity and specificity. In an ...
Near infrared fluorescent sensors for selective glucose recognition
(University of Missouri--Columbia, 2021)
, near IR pH probes based on cyanine fluorophores were designed and synthesized. These probes provided insight into practicality of cyaninebased near IR sensors for use in vivo and served as a starting point to achieve the ultimate goal of glucose...
Aza-analogues of distyrylbenzene (DSB) synthesis, structures, and properties of 1,4-phenylenediamine bisimines (PDABI)
(University of Missouri--Columbia, 2006)
bisimines. Chapter 4 is a conformation and packing study of planar azine analogues chlorobenzaldazine and bromobenzaldazine....
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
-activity relationships, a series of N-phenylpropyl- N'-benzylpiperazine and N-phenylpropyl-4-benzylpiperidine analogs systematically substituted on both phenyl rings was synthesized. These ligands were specifically designed to have certain substituents and substitution...
Synthesis and evaluation of [105]Rhodium (III) complexes of phosphine chelate systems
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] [Superscript 105]RH has attractive nuclear and chemical properties to be investigated as a nuclide for development of potential radiopharmaceuticals. ...
Ligands for the sigma receptor and the mu-opioid receptor
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family with two subtypes: sigma-1 and sigma-2. In order to conduct structure-activity relationship studies (SAR), a series of specific 1-phenylpropyl-4-benzylpiperidine and 1-phenylpropyl-4- benzylpiperazine...
Studies on the nucleophilic substitution reactions of a dimeric cyclopentadienone
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Nucleophilic substitution reactions of 3,5-Dibromo-3a,4,7,7a-tetrahydro-4,7-methano-indene-1,8-dione (48) have been studied. Amines, thiols and alcohols have been employed...
Intermolecular (4+3) cycloaddition reaction of oxidopyridinuim ions with silylated dienes, exploring the oxidation chemistry and photochemistry of cycloadducts
(University of Missouri--Columbia, 2022)
carbon was unsuccessful. Based on the proposed mechanism and the product formation, HFIP acted as the nucleophile. An extension of the aforementioned study investigated the efficacy of the (4+3) cycloadducts as reactants in a [2+2] photocycloaddition...
Technetium and rhenium schiff base complexes for nuclear medicine
(University of Missouri--Columbia, 2019)
by microwave assisted synthesis. A two-step (one-pot) procedure was utilized. In the first step, the Re(V) precursor (nBu4N)[ReOCl4] is reacted with the Schiff base ligand forming trans-[ReOCl(tmf2en) in situ. In the second step, a tertiary phosphine ligand...
Investigation of CO2 capture systems, Lewis acid-base pairs, and oscillating reactions with electronic structure theory and kinetics-based approaches
(University of Missouri--Columbia, 2020)
. From the outset, this quest was pursued as an interdisciplinary project between chemistry and mathematics. My work with the dynamics group resulted in Chapters 3 and 4 of the present dissertation. Chapter 3 is a re-evaluation of the video-based kinetic...
From carbon to copper : studies of novel nanomaterials
(University of Missouri--Columbia, 2007)
of two particular types of nanomaterials: single-walled carbon nanotubes and copper-based coordination polymers. The synthesis of single-walled carbon nanotube gels and foam is detailed, and a series of techniques including scanning electron microscopy...
Design and construction of multicomponent spheroidal assemblies on the nano-scale via the self-assembly approach
(University of Missouri--Columbia, 2006)
spherical multicomponent assemblies via the selfassembly approach. Chapter 2 will describe the formation of very large molecular capsules based upon the self-assembly of six macrocycles called the C-alkylpyrogallol[4]arenes. These molecular capsules are held...
Metabolically activated heterocyclic N-oxide compounds for killing and visualizing hypoxic cancer cells
(University of Missouri--Columbia, 2009)
on the benzotriazine-1-oxide substrates involving various 3-aryl, and 3-cyclopropyl boronic acid to build a series of TPZ analogues. In addition to this work, we prepared novel 3-cyclopropyl-1,2,4-benzotriazine 1,4- dioxide which damages DNA under bioreductive hypoxic...