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Enhanced Etoposide Solubility and Anticancer Activity using Complexation and Nanotechnology
(2021)
drawbacks which hamper etoposide activity. The central hypothesis of this work is to enhance etoposide (VP-16) solubility, dissolution, and improve its antitumor activity using emerging formulations strategies such as complexation and nanotechnology. To test...
Uranium Oxides for Solid-State Direct-Conversion Neutron Detection
(2020)
to achieve absorption probabilities of a few percentages: 1.5–4% for 10 MeV neutrons for natural uranium oxides, ∼2% for 1 MeV neutrons for ²³⁵U-based uranium oxides, and 7–9% for thermal neutrons for natural uranium oxides, assuming each detector is 1 cm...
Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
(2022)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) based methods for quantifying cell wall biosynthesis intermediates. These include LC-MS/MS methods for quantifying cytoplasmic UDP-linked peptidoglycan biosynthesis intermediates. Retention...
Plasma-enhanced molecular layer deposition (PEMLD) of boron carbide dielectrics from carboranes for interconnect and patterning applications
(2022)
-level interconnects were introduced that require complex process. Such processes require multiple materials that can act as diffusion barriers, copper capping layers, etch stops, hard masks, etc. Currently, silicon-based materials are being used to fulfill...
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)
roles in many biological systems and processes. Amino acids are polar analytes and are difficult to separate on traditional silica based stationary phases in reverse phase chromatography to allow accurate quantification in their natural form. In part I...
Amorphous hydrogenated boron carbide for solid-state direct-conversion thermal neutron detection
(2021)
Amorphous hydrogenated boron carbide (a-BC:H) is one of a very limited number of neutron-sensitive materials. It has been studied over the last three decades for solid-state thermal neutron detection due to its high ...
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)
Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a gram-positive bacteria, the peptidoglycan layer is thick as compared to gram negatives ...
Development of Closomer And MIBG based Nanoformulation: Application to HIV Prevention and Neuroblastoma Therapy
(2023)
This dissertation is divided into two parts. Part #1 focuses on the development and characterization of closomer based nanoformulation for the prevention of HIV/AIDS sexual transmission. Part #2 focuses on the development and characterization of a...
Ab Initio Study of Amorphous Zeolitic Imidazolate Framework (A-ZIF) and Pyrophosphate crystals
(2020)
due to the sudden formation of N-N bond pairs. Systematic expansion of a-ZIF retains the framework softness until it fractures at high strain. Based on the expansion data, we propose an empirical formula for super-soft materials, which is in line...
Chemical and biochemical applications of vibrational spectroscopy
(2022)
Vibrational spectroscopy is a technique that probes a molecule’s vibrational modes via infrared absorption and Raman scattering, and is often used as a tool for characterization and/or functional group determination. Because ...
Smart hydrogel for enzyme responsive vaginal delivery of anti-HIV peptide therapeutics
(2021)
In response to an urgent need for advanced formulations for the delivery of anti-retrovirals, a stimuli sensitive hydrogel formulation that intravaginally delivers HIV-1 entry inhibitor upon being exposed to a specific ...
Development and Evaluation of 3D-Printed Cardiovascular Stents
(2022)
Biodegradable stents (BDS) could be a promising alternative to the conventional metallic stents for the treatment of atherosclerosis which is a coronary artery disease (CAD). Three-dimensional (3D) printing technique has ...
Aminoxyl Catalyzed Electrochemical Ethanol Detection: Development of a New Breathalyzer Using Molecular Catalysis
(2021)
of an electrochemical ethanol sensor for breath analysis with experimental details described in chapter two. Our functional sensing element consists of a screen-printed electrode in which the graphene oxide-based working electrode is modified with aminoxyl derivatives...
Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
(2020)
Disorders affecting the posterior segment of eyes represent a significant burden to healthcare and patients’ wellbeing. Among the back of the eye disorders, age-related macular degeneration (AMD) is one of the major ailments ...
Novel nanocarriers to improve drug delivery for age-related macular degeneration
(2021)
Visual impairment affecting the posterior segment of the eye is a significant health problem causing a deterioration of the quality of life of millions worldwide. Age-related macular degeneration (AMD) is ranked third on ...
On the advancement of core/shell titanium dioxide nanomaterials for microwave absorption
(2020)
Controlling the interactions between incident electromagnetic energy and matter is of critical importance for many civil and military applications, such as photocatalysis, solar cells, optics, radar detection, communications, ...