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Evaluation of Cement-Based Reactive Media for Contaminant Remediation
(University of Missouri -- Kansas City, 2018)
Water contaminated with heavy metals, arsenic, and other industrial pollutants
poses a severe risk to human health. Reactive media present an opportunity to intercept
contaminants but have high material or environmental ...
Synthesis and Electrocatalytic Properties of Structure Engineered First-Row Transition Metal Derivatives
(University of Missouri--Kansas City, 2018)
Hydrogen is a green energy carrier, producing only water when combusted, and a
hydrogen economy has been considered the ideal green economy for human society. Water
electrolysis can produce high-purity hydrogen on a ...
Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
(University of Missouri -- Kansas City, 2017)
Pentablock (PB) copolymers have been successfully synthesized for long term delivery in
the treatment of posterior segment ocular diseases. PB copolymers are comprised of FDA
approved biodegradable polymer such as ...
Design and Evaluation of HIV Microbicides Loaded mucoadhesive Nanoformulation
(2015)
,
there is an urgent need to develop a formulation with proper vaginal retention time for the
topical application of anti-HIV microbicides. The aim of this dissertation is to test the
hypothesis that a mucoadhesive polymer based nanomedicine can prolong the contact...
Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
Photoemission Spectroscopy Studies of New Topological Insulator Materials
(2015-08-04)
As the size of a solid shrinks, the ratio of surface area to bulk volume grows and
surface effects become more important. In a world where technologies advance with the
shrinking size of electronic devices, one phase of ...
Synthesis, Characterization and Device Studies of Conjugated Foldamers
(University of Missouri--Kansas City, 2017)
Conjugated polymers have found a wide range of electronic applications in last few
decades due to their superior combination of optoelectronic, mechanical properties, and
solution processability. In the past few years, ...
In Pursuit of Extraordinarily Twisted Acenes
(2015-05-26)
Longitudinally twisted acenes are a topologically interesting class of polycyclic aromatic hydrocarbons (PAHs), and it could be argued that they have quite beautiful chemical structures, too. X-ray crystal analysis of many ...
Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
(2015)
Since their discovery in the Buszek laboratories in 2007, the indole arynes and their cycloaddition chemistry has demonstrated its significance in achieving the total synthesis of biologically active indole alkaloid natural ...
Polycyclic Aromatic Hydrocarbon (PAH)-Based Conjugated Macrocycles and Polymers For Electronic Applications
(2014)
applications. Specifically, two imine-based shape-persistent macrocycles containing triphenylene building blocks have been synthesized. Their stable conformations are predicted by quantum mechanical calculations and confirmed by 2D NOESY NMR measurements...
Novel Polycyclic Benzannulated Indole Scaffolds via Indole Aryne Cycloaddition, Pd (0)-Catalyzed Cross-coupling and ROM/RCM methodologies: Their Applications to Library Development and Drug Discovery
(2014)
Dissertation under the direction of Keith R. Buszek, Ph.D., Professor of Chemistry,
University of Missouri-Kansas City.
Heterocyclic chemistry is one of the most valuable sources of novel compounds with
diverse biological ...
Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
(2015-08-04)
The objective of this study was to develop a clear, aqueous drug loaded
nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic
drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone ...
Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention
(University of Missouri--Kansas City, 2016)
The objective of this dissertation is to design and optimize a nanoformulations
(nanoparticle and nanofiber) delivery system loaded with anti-HIV topical microbicides for
HIV prevention in women.
In chapters 1 and ...
Raman, Infrared and Microwave Spectra, Conformational Stability, R₀ Structural Parameters and Vibrational Assignments of Some Organoamines, Organophosphines, Alcohols And Substituted Four And Five Membered Rings
(2014)
, to be 83 ± 8 cm⁻¹ (0.99 ± 0.10 kJ/mol), the third stable conformer, Gt, to be 235 ± 11 cm⁻¹ (2.81 ± 0.13 kJ/mol). For 2,2,2 trifluoroethylamine, the enthalpy difference has been determined to be 267 ± 27 cm⁻¹ (3.19 ± 0.32 kJ mol⁻¹) with the trans conformer...
Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases
(2013)
(TB) (PCL-PEG-PCL, B-A-B) and PB (PLA-PCL-PEG-PCL-PLA (C-B-A-B-C) and PEG-PCL-PLA-PCL-PEG (A-B-C-B-A)) copolymers based thermosensitive gelling polymers. We have observed distinct effect of block arrangement and molecular weights of block copolymers...
Topical Clear Aqueous Nanomicellar Formulation for Anterior and Posterior Ocular Drug Delivery
(University of Missouri–Kansas City, 2015)
The objective of this study was to develop a clear, aqueous drug loaded nanomicellar formulation (NMF) for the back-of-the-eye delivery. Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, ...
Evaluation of siRNA mediated Silencing of IKKα in Prostate cancer and CD40 in Type-1 Diabetes
(2014-09-30)
The objective of this dissertation is to present the various therapeutic approaches for two distinctly different diseases, prostate cancer and type-1 diabetes. Our objective (1) for prostate cancer is to evaluate the siRNA ...
Recent Advances in Hetaryne Chemistry. Efforts Toward the Development of a Single Platform for the Generation of 4,5-, 5,6-, and 6,7-Indole Arynes
(University of Missouri--Kansas City, 2017)
In the beginning of 2007, indole arynes and their cycloaddition chemistry were discovered
by Buszek laboratories. Since then, indole arynes and their cycloaddition chemistry have
demonstrated their value in the ...
Conformational and Structural Determinations of Substituted Four and Five Membered Rings by Infrared, Raman, and Microwave Spectral Studies
(2014)
Studies of the structure and conformational stabilities of molecules have become
increasingly important due in part to advances in the fields of biochemistry and nanochemistry.
Specifically the conformation of organoamines ...
Deciphering of packing signal hypothesis in bacterophage RNA recognition by the MS2 capsid protein in virus assembly
(University of Missouri -- Kansas City, 2018)
MS2 is a classical example of a single-stranded RNA virus for which the genomic
RNA plays pivotal roles in the virus assembly process. Multiple dispersed RNA se
quence/structure motifs, packaging signals (PSs) varying ...