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Investigation of the thermostability and activity of biomolecules in bio-friendly deep eutectic solvents
(University of Missouri--Columbia, 2023)
DESs in an array of biomolecule-driven purposes and illustrate the versatility and potential of these unique, environmentally responsible solvents for next-generation biotechnological and biomedical applications....
The synthesis and characterization of 1,1'-disubstituted ferrocene imine Schiff base ligand systems for use as potential environmental heavy metal cationic sensors
(University of Missouri--Columbia, 2008)
Heavy metals in the environment such as Cd, Hg and Pb are toxic to life forms. They can enter the ecological system through both natural and industrial sources. By developing chemical sensors that can detect these metals, ...
Metabolically activated heterocyclic N-oxide compounds for killing and visualizing hypoxic cancer cells
(University of Missouri--Columbia, 2009)
Tirapazamine (TPZ) is currently undergoing a variety of phase I, II, and III clinical trials for the treatment of various human cancers. TPZ derives its medicinal activity by inducing DNA damage in poorly oxygenated tumor cells. Selective...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
) incorporating a radiolabel directly into a small molecule, or 3) using the bifunctional chelate approach to indirectly label peptides or antibodies. The final model is the focus of this work. The bifunctional chelate approach involves using a chelate that forms...