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Mathematical Analysis of Compressive/Tensile Molecular and Nuclear Structures
(2015-06-19)
Mathematical analysis in chemistry is a fascinating and critical tool to explain
experimental observations. In this dissertation, mathematical methods to present
chemical bonding and other structures for many-particle ...
Evaluation of siRNA mediated Silencing of IKKα in Prostate cancer and CD40 in Type-1 Diabetes
(2014-09-30)
expression and examine its effects on tumor cell invasiveness and growth, and (2) for type-1 diabetes is to develop a stable transgene delivery system that can infect dividing as well as quiescent cells, such as pancreatic islets. In chapter 1 and 2...
Preparation, Characterization and Performance Study of Modified Titanium Dioxide Nanocrystals for the Lithium-Ion Battery
(2015-08-04)
The lithium-ion battery is one of the most widely used rechargeable batteries in
today’s life. As an energy storage device, it can convert the stored chemical energy into
electrical energy when it is being used. Titanium ...
Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma
(2020)
Dense desmoplastic stroma is a fundamental characteristic of pancreatic ductal adenocarcinoma (PDAC) and comprises up to 80% of the tumor mass, which acts as a barrier that impedes the delivery of antitumor drugs into the tumor microenvironment...
Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
Plasma-enhanced molecular layer deposition (PEMLD) of boron carbide dielectrics from carboranes for interconnect and patterning applications
(2022)
. But this has come at a price of introducing complex patterning processes for achieving feature sizes not accessible through traditional lithography. Also, to connect these huge numbers of transistors, single-level interconnect was not sufficient so multi...
Development of Closomer And MIBG based Nanoformulation: Application to HIV Prevention and Neuroblastoma Therapy
(2023)
This dissertation is divided into two parts. Part #1 focuses on the development and characterization of closomer based nanoformulation for the prevention of HIV/AIDS sexual transmission. Part #2 focuses on the development and characterization of a...
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)
Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a gram-positive bacteria, the peptidoglycan layer is thick as compared to gram negatives and is made up of peptide...
Development of drug conjugates in cancer therapy and evaluation of dual siRNA silencing effect on breast cancer growth and invasion
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to present various approaches for treatment cancer,
which is the leading cause of death worldwide. Compared to other disease, cancer has many
unique biological characteristics that ...
Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
(University of Missouri--Kansas City, 2012)
The objective of this dissertation is to develop siRNA-based cancer therapeutics. In
chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based
therapy, as well as various siRNA delivery systems. ...
Synthesis, Characterization and In-vivo Testing of Photoactivatable Insulin Depots for Continuously Variable and Minimally Invasive Insulin Delivery
(University of Missouri -- Kansas City, 2019)
Proteins are macromolecules involved in a diverse array of functions. Mutations or
abnormal levels of proteins are indicated in several diseases. Despite showing early
promise, the translation of protein therapeutics ...