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Ligands for the sigma receptor and the mu-opioid receptor
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family with two subtypes: sigma-1 and sigma-2. In order to conduct structure-activity relationship studies (SAR), a series of specific 1-phenylpropyl-4-benzylpiperidine and 1-phenylpropyl-4- benzylpiperazine...
Anisotropic organic materials : ferroelectric crystals and spin-polarized radicals
(University of Missouri--Columbia, 2007)
,4-diphenyl-1,3-butadiene is analyzed with various methods. Toward quasienantiomeric non-linear crystals, 1- methyl-1,3,6-triphenyl-7-(E-2-phenylpropenyl)-1,2-dihydronaphthalene is probed in molecular interactions, synthesis, and chiral separation. In Chapter...
Design and construction of multicomponent spheroidal assemblies on the nano-scale via the self-assembly approach
(University of Missouri--Columbia, 2006)
spherical multicomponent assemblies via the selfassembly approach. Chapter 2 will describe the formation of very large molecular capsules based upon the self-assembly of six macrocycles called the C-alkylpyrogallol[4]arenes. These molecular capsules are held...
Arsenic-72, 77 as a matched pair radiopharmaceutical for imaging and radiotherapy
(University of Missouri--Columbia, 2018)
). Radioimmunoimaging and therapy commonly use antibodies (or antibody fragments) as targeting biomolecules, and may take a few days to accumulate in tumor cells. Thus they require radionuclides with longer half-lives. Arsenic-72 ([beta]+, 26 hour half-life) and 77As...
Design and synthesis of group 8 transition metal complexes for C-C bond forming valorization of carbon dioxide
(University of Missouri--Columbia, 2023)
development studies have focused on the transformation of CO2 into C1 products, such as carbon monoxide or methanol, the reductive coupling of CO2 to produce new C-C bonds is an emerging field that has the potential to produce valuable commodities in a...
Computational studies of three chemical systems
(University of Missouri--Columbia, 2011)
are examined to better understand the process by which self-assembly of the nanocapsule occurs. The second topic is the study of the addition of H2O and O2 to vanadyl complexes of the form [VOX(NCCH3)]+ where X = F-, Cl-, Br-, I-, and OH-. Changing the identity...
Trithiol ligand development for radioarsenic and radioantimony toward potential theranostic radiopharmaceutical agents
(University of Missouri--Columbia, 2022)
and 72As is described. A new trithiol chelate with two carboxylic acid groups was developed and then conjugated to the RM2 peptide targeting gastrin releasing peptide receptors on prostate cancer with two different linkers, (Ser)2 and Glu...
Sustainable chemical approaches to two-dimensional nanosheets and mesoporous platforms and catalysts
(University of Missouri--Columbia, 2017)
, there is widespread recognition of the need to adopt cleaner, sustainable practices to enhance the quality and control of commercial products through a knowledge based approach. The goal for the researchers in sustainable chemistry is to meet the objective without...
Broadband rotational spectroscopy in Laval flows: applications in astrochemistry and dynamics
(University of Missouri--Columbia, 2022)
that govern the final product branching fractions observed in these dissociations. Additionally, radical-radical reaction dynamics of NH2/ND2+ C3H3 and NO + C3H3 were studied employing quasi uniform flows. These reactions showcase the power of CPUF ability...
Development of novel fluorescent sensors for targeting biologically relevant molecules
(University of Missouri--Columbia, 2023)
relevant molecules and will be discussed herein. Firstly, a new strategy was devised to synthesize photoactive C,O-BODIPY substituted dyes for capturing 18F so that they can used as dual modality PET/Fluorescence imaging probe for labeling peptide...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
-activity relationships, a series of N-phenylpropyl- N'-benzylpiperazine and N-phenylpropyl-4-benzylpiperidine analogs systematically substituted on both phenyl rings was synthesized. These ligands were specifically designed to have certain substituents and substitution...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
. For instance, alpha and beta particles are used for treatment of disease, while gamma and positron emissions are useful for disease detection. There are three main ways to develop a radiopharmaceutical drug; 1) through direct administration of a radionuclide, 2...
Development and application of inductively coupled plasma mass spectrometry techniques to investigate platinum chemotherapy agents
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cisplatin (cDDP), the first platinum chemotherapy compound, has been used in cancer chemotherapy in human beings and animals for more than thirty years. Satraplatin (JM216...
2,1-Benzothiazines : preparation and reactivity
(University of Missouri--Columbia, 2010)
of efforts toward the syntheses of several families of enantiomerically pure 2,1-benzothiazine ligands. These ligands are unique in that they contain a chiral sulfoximine. Several 2,1-benzothiazine ligands were prepared in single one-pot syntheses and others...
Experimental and theoretical studies of CO2 capture from air and of crystalline, ferroelectric, non-linear optical materials
(University of Missouri--Columbia, 2022)
approaches. In Chapter 1 to 3, we focused on a Rubisco inspired CO2 capture material, which is made of tetrapeptide KDDE. In chapter 1, we investigated the thermochemistry of the small amine system with full conformational space and determined the best method...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
of the prostate cancer PC-3 xenografts in SCID mouse was performed at 1-hr post-injection of [superscript 111]InDOTA-Conjugate. The results obtained from the presented study demonstrate the potential of using bombesin analogs possessing antagonist C...
Molecular dynamics simulations of shock-induced pore collapse in single crystal [beta]-HMX
(University of Missouri--Columbia, 2023)
that a single simulation for a particular scenario can be interpreted as representative. The conclusions from Chapter 2 were then used to guide the design of the MD systems in the second and third study (Chapter 3 4), where MD is used as "ground truth...
Development of selective high-affinity fluorescent sensors for imaging neurotransmitters and application in cells and tissue
(University of Missouri--Columbia, 2019)
Herein, we develop a series of selective fluorescent sensors based on a quinolone core designed to image neurotransmitters catecholamines, serotonin and glutamate. Included are the main design strategy, synthesis, spectroscopic data (UV...
Studies of natural products that reveal novel strategies for efficient modification of DNA
(University of Missouri--Columbia, 2006)
novel molecular recognition features of the natural product azinomycin using similar tools (Chapter 4). We characterized novel, reversible chemical reactions of leinamycin (Chapter 3). Amongst these were reversible DNA-alkylation and reversible adduct...
Investigation of the thermostability and activity of biomolecules in bio-friendly deep eutectic solvents
(University of Missouri--Columbia, 2023)
The solvent environment of a biomolecule is critical to its optimal performance in various scenarios, including biocatalysis, drug delivery, therapeutics, and biosensing. This dissertation mainly discusses the implementation of deep eutectic...