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Organoisocyanates: the conformational stability determination by infrared, raman and microwave spectroscopy and ab initio calculation
(University of Missouri-Kansas City, 2012)
Conformational stability studies have been carried out for several quasilinear organoisocyanates and organoisothiocyanates. The infrared and Raman spectra in the gaseous, liquid and solid phases have been recorded as well ...
Protein production and applications of NMR in pharmaceutical sciences
(2014-08-28)
The objective of Part I (Protein production for structural elucidation using NMR) is to design and develop strategies of producing amyloid beta protein for structural analysis using NMR. Amyloid beta oligomers are considered ...
Clear, Aqueous Topical Nanomicelle Formulation For Diabetic Macula Edema
(University of Missouri -- Kansas City, 2018)
The objective of this study was to develop a clear aqueous mixed nanomicellar
formulation (NMF) of hydrophobic drugs for diabetic macula edema. The hydrophobic
drugs include triamcinolone acetonide (TA), fluocinolonce ...
Novel targeted lipid prodrugs to improve cellular absorption of acyclovir and topical delivery to the eye via nanomicellar approach
(2013)
Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the
sodium dependent multivitamin transporter (SMVT) on the intestine and cornea to
facilitate ACV cellular transport. All the prodrugs were screened ...
Fomulation and Delivery of Drugs for Macular Edema and Retinoblastoma; Synthesis and In Vitro Characterization of Doxorubicin Loaded Surface Modified Nanoparticles Using PLGA-PEG-PLGA Polymer
(University of Missouri--Kansas City, 2011-01-20)
Macular edema (ME) is caused by central extravascular swelling of the macula resulting in a significant loss of visual activity. Corticosteroids are widely used in the treatment of ME. In this project, nanoparticles of ...
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)
Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a gram-positive bacteria, the peptidoglycan layer is thick as compared to gram negatives ...
Engineering of Human Acid Phosphatase Enzyme Sensitive Nanomedicine for HIV/AIDS Prevention by Topical Route
(University of Missouri -- Kansas City, 2018)
This study is divided into two aims. Aim #1 focuses on the development and
characterization of tenofovir (TFV) loaded a stimuli sensitive nanomedicine against male to
female HIV/AIDS infection. Aim #2 focus on the ...
Prodrug Approach to Improve Oral and Brain Absorption of HIV Protease Inhibitor, Lopinavir
(2014)
The main objective of this project is to develop prodrug strategies to circumvent efflux
pumps such as P-glycoprotein (P-gp) and multidrug resistance associated proteins (MRPs),
thereby enhancing oral and brain absorption ...