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Metabolomics and chemical library screening for antibacterial drug discovery
(2020)
(DNA)/nucleosides to assess the activity of Ten-Eleven Translocation 2 (TET2) enzyme. Methylation of one of the DNA bases, cytosine at the C-5 position (5-methylcytosine, 5mC) plays a crucial role in epigenetic transcriptional regulation. TET-family...
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)
Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a gram-positive bacteria, the peptidoglycan layer is thick as compared to gram negatives ...