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Metabolomic Analysis of Bacterial Cell Wall Intermediates Using LC-MS/MS: Peptidoglycan Pathway Response to Different Antibiotics
(University of Missouri--Kansas City, 2017)
The bacterial cell wall is made up of peptidoglycan (PG) and its synthesis is of
interest as a target for several antibiotics and for new inhibitor development. Peptidoglycan
biosynthesis is a complex process which ...
Engineering of Human Acid Phosphatase Enzyme Sensitive Nanomedicine for HIV/AIDS Prevention by Topical Route
(University of Missouri -- Kansas City, 2018)
This study is divided into two aims. Aim #1 focuses on the development and
characterization of tenofovir (TFV) loaded a stimuli sensitive nanomedicine against male to
female HIV/AIDS infection. Aim #2 focus on the ...
Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
(2015)
Since their discovery in the Buszek laboratories in 2007, the indole arynes and their cycloaddition chemistry has demonstrated its significance in achieving the total synthesis of biologically active indole alkaloid natural ...
Ritonavir - A Novel Multidrug Resistance Modulator in Cancer Chemotherapy and Ocular Neovascular Diseases
(2014-08-28)
Multidrug resistance (MDR), a clinical outcome characterized by subtherapeutic
intracellular drug concentration, is one of the predominant factors limiting effective cancer
chemotherapy. Several possible mechanisms and ...
Evaluation of therapeutic effect of PCBP2 siRNA on hepatic stellate cells and development of a streptavidin-based siRNA delivery system
(2014)
Type I collagen accumulates during liver fibrosis primarily because α-complex protein-2 (αCP2), encoded by the poly(rC) binding protein 2 (PCBP2) gene, binds to the 3′end of the collagen mRNA and increases its half-life. Study in chapter 3 aimed...
Total synthesis of (±)-cis-trikentrin B, (±)-herbindole A and (±)-herbindole B. investigation into the regioselectivity of 6,7-Indole aryne cycloadditions
(2013)
Total synthesis of benzannulated indole alkaloid natural products (±)-cis-trikentrin B,
(±)-herbindole A and (±)-herbindole B via intermolecular indole aryne cycloaddition are
described. The 5,6,7-tribromoindole was ...
Establishing Metronidazole as a Novel Biomarker of CYP2A6 Activity
(University of Missouri -- Kansas City, 2018)
CYP2A6 is a polymorphically expressed enzyme with variation associated with
smoking behavior, cessation success, lung cancer risk, and differential drug exposure to
numerous medications including anti-infectious and ...
Proinflammatory Cytokine / Chemokine Expression in Human Astrocytes: Induction by HIV-1 Nef
(2014)
. The importance of HIV-1 accessory protein Nef has been well established in the pathology of AIDS in the peripheral. The presence of HIV-1 Nef mRNA and protein has also been demonstrated in astroctytes of the brain, however, the role of HIV-1 Nef...
Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions
(2014-08-28)
Tissues such as liver, kidney, brain and intestine expresses membrane transporters which play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of functionality and molecular expression ...
Role of cytochrome P450 enzymes on alcohol/nicotine-mediated oxidative stress and cytotoxicity in monocytes/astrocytes: Implications for HIV-infected alcohol/tobacco users
(University of Missouri--Kansas City, 2012)
that 1) CYP2A6, CYP2E1 and CYP3A4 are induced by alcohol in U937 monocytes/macrophages, while only CYP2E1 is induced by alcohol at both mRNA and protein levels in SVGA astrocytes, 2) CYP2A6 metabolizes nicotine in U937 macrophages and SVGA astrocytes...
Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
(University of Missouri -- Kansas City, 2019)
Overall aim of this research project is to develop folic acid targeted nanomicelles
loaded with insoluble hydrophobic drugs for delivery to posterior segment of the eye.
Retinoblastoma and uveitis are diseases that ...
Molecular assembly of polycyanoarenes with silver salts and synthesis of polycyclic aromatic hydrocarbonds
(University of Missouri--Kansas City, 2012)
This dissertation encompasses the investigation of two distinct subjects. In the first
part, which is in the area of molecular self-assembly, the complexation of organonitrile aryl
compounds with three different types ...
Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
(University of Missouri -- Kansas City, 2018)
Prostate cancer is the most common male malignancy and remains the second-leading
cause of death due to cancer in American men. While surgery and radiation are effective in
prostate cancer therapy at early stages, the ...
Synthesis, Characterization and In-vivo Testing of Photoactivatable Insulin Depots for Continuously Variable and Minimally Invasive Insulin Delivery
(University of Missouri -- Kansas City, 2019)
Proteins are macromolecules involved in a diverse array of functions. Mutations or
abnormal levels of proteins are indicated in several diseases. Despite showing early
promise, the translation of protein therapeutics ...
Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
(University of Missouri--Kansas City, 2016)
The objective of this dissertation is to present two approaches to identify Hepatic
Stellate Cells (HSCs) targeting ligands using phage-display library biopanning and
systematic evolution of ligands by exponential ...
Development of Advanced Delivery Systems for Microbicides
(2016)
HIV/AIDS still continues to be a pandemic and global emergency and is a leading cause of
death among the women of reproductive age (15-49 yr). Women are more vulnerable for HIV infection
due to anatomical and physiological ...
Evaluation of siRNA mediated Silencing of IKKα in Prostate cancer and CD40 in Type-1 Diabetes
(2014-09-30)
, the effect of RNAi mediated CD40 gene silencing on Insulinoma endothelial cells (islet β cell) and rat pancreatic islets was evaluated. Three siRNAs targeting different regions of CD40 mRNA were designed and the silencing efficiency was estimated at m...
Novel Dichloroacetate Prodrugs for Improved Targeting of Breast Cancer Chemotherapeutics
(University of Missouri -- Kansas City, 2019)
It is well documented that most cancer cells utilize aerobic glycolysis or Warburg
metabolism instead of mitochondrial oxidative phosphorylation for cell energy production.
Dichloroacetate is a synthetic small molecule ...
Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
(University of Missouri -- Kansas City, 2017)
The objective of this dissertation is to discover PSMA (Prostate Specific Membrane
Antigen)-specific peptide ligands using phage display and employ peptide nucleic acid as
a complementary linker to attach chemical ...
The effects of HIV-1 viral protein r (vpr) and anti-retroviral drugs in the brain: Implications in HIV-1 associated neurocognitive disorders
(University of Missouri--Kansas City, 2016)
The morbidity and mortality of HIV-1 infected individuals has declined significantly
by the introduction of highly active antiretroviral therapy (HAART). Nevertheless, different
forms of HIV-1 associated neurocognitive ...