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Functional Analysis of TET-Family 5-Methylcytosine Dioxygenases in Non-CpG DNA Demethylation
(2023)
One of the most widely studied epigenetic marks in DNA is 5-methylcytosine (5mC). Research has indicated that in the mammalian genome around 5-6% of all cytosines are methylated (5mC), with a strong preference for the CpG dinucleotide context...
Novel Dichloroacetate Prodrugs for Improved Targeting of Breast Cancer Chemotherapeutics
(University of Missouri -- Kansas City, 2019)
It is well documented that most cancer cells utilize aerobic glycolysis or Warburg
metabolism instead of mitochondrial oxidative phosphorylation for cell energy production.
Dichloroacetate is a synthetic small molecule ...
Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases
(2015-06-02)
Hypoxia-inducible-factor (HIF)-mediated expression of pro-angiogenic genes under
hypoxia is the fundamental cause of pathological neovascularization in ocular diseases and
cancers. Thus, the inhibitors of the HIF pathway ...
Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
(2014-08-28)
The research presented in this dissertation is aimed at understanding the epigenetic
regulation of the HIF pathway and the efficacy of treatment for retinal diseases and
hemangioblastomas using HIF pathway inhibitors. ...
Novel in vitro cell culture models for studying pharmacokinetic drug-drug interactions following oral administration
(University of Missouri--Kansas City, 2011-09-21)
) as well as MRP2 and CYP3A4 (MMrC). These were characterized by using expression and activity studies. Cellular transport study of 200 μM cortisol, was performed to determine their combined activity. The study was carried across control, single transfected...