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Molecular mechanisms controlling endothelial cell-pericyte tube coassembly during vascular morphogenesis
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] From the onset the goal of this thesis work was to determine the role that a novel class of growth factors, i.e. hematopoietic cytokines, was playing ...
Molecular physiology and pharmacology of the CFTR chloride channel
(University of Missouri--Columbia, 2012)
Cystic fibrosis transmembrane conductance regulator (CFTR) is the only ATP binding cassette (ABC) protein that functions as an ion channel. The clinical importance of CFTR lies in the fact that its malfunction causes the ...
The role of adipose tissue in the regulation of endothelial function in type 2 diabetes : mechanisms and therapeutic implications
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The prevalence of obesity and diabetes is rising dramatically worldwide. Increased adiposity is associated with elevated cardiovascular risk factors, ...
Metabolic and autonomic nervous system effects of bariatric surgery
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Despite avid attempts, non-surgical methods such as diet aids, behavioral modification and exercise are typically unsuccessful in achieving long term ...
CFTR gating mechanism : the role of dimerization of nucleotide binding domains
(University of Missouri--Columbia, 2009)
The chloride channel, cystic fibrosis transmembrane conductance regulator (CFTR) has two membrane spanning domains (MSD), forming the channel pore, and two nucleotide binding domains (NBD), controlling the channel gating ...
Dendritic cells contribute to perivascular adipose tissue dysfunction in type 2 diabetes
(University of Missouri--Columbia, 2017)
physiological conditions, we examined the effects of fat from db/db mice on vascular function. The data showed that in db/db mice, both of these 'vaso-protective' effects were lost at early (6-10 weeks) and later (18-22 weeks) stages of T2DM in the presence...
Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Rho GTPases regulate a diverse spectrum of cellular functions involved in vascular morphogenesis. Here, we show that Cdc42 and Rac1 play a key role ...
Endothelial phenotype differs by both sex and vessel function
(University of Missouri--Columbia, 2017)
. While it is often presumed that all non-specialized endothelial cells are the same, and thus will have the same response to various pharmacological agents, disease states, and stimuli, this may not be true. Our goal is to understand if endothelial cell...
Mechanisms of BKCa channel agonist NS-1619-elicited protection against oxidative stress from venules to arterioles
(University of Missouri--Columbia, 2011)
the progression of tissue injury, it also initiates a complex series of microvascular inflammatory changes which paradoxically induce additional cellular damage beyond ischemia alone. Pharmacological preconditioning is a powerful protective intervention against...
The effect of troponin I phosphorylation on the steepness of the Frank-Starling relationship
(University of Missouri--Columbia, 2013)
Heart failure begins with a reduction in the contractile strength of the cardiac myocytes (systolic dysfunction.) Cardiac myofibrils compensate via sympathetic activation to maintain adequate cardiac output. Beta-adrenergic ...
Functional differences between pericytes and vascular smooth muscle cells during vascular morphogenesis
(University of Missouri--Columbia, 2011)
During vascular morphogenic events, mural cells are recruited to developing endothelial tubes to aid in stabilization and maturation of the new vessels. There are two known types of mural cells, pericytes and vascular ...
Receptor for advanced glycation end-products blockade improves endothelial dependent vascular function in atherosclerotic mice
(University of Missouri--Columbia, 2012)
Atherosclerosis is a progressive inflammatory disease that is present in large vessels in the body. We hypothesized that either adiponectin treatment or soluble Receptor for Advanced Glycation Products (sRAGE) treatment ...
The effects of sex and ovarian hormones on arterial baroreflex control of blood pressure in humans
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The arterial baroreceptors are responsible for mediating rapid reflex adjustments to acute cardiovascular stressors via modulating autonomic nervous ...
Histone H3 phosphorylation and phosphoacetylation in the liver of rats treated in vivo with acute ethanol
(University of Missouri--Columbia, 2011)
Epigenetic histone modification is emerging as a critical player in the cellular actions of ethanol. In this context, we administered ethanol intraperitoneally to rats, to mimic binge drinking in humans. A dose response ...
Microenvironmental regulation of ovarian cancer dissemination via activation of the Wnt signaling pathway
(University of Missouri--Columbia, 2012)
Disseminating single cells and multicellular aggregates (MCAs) and experience compressive forces exerted upon them by ascites fluid and are exposed to lysophosphatidic acid, aberrantly adhesive mesothelium and a collagen-rich ...
Myofibrillar regulatory mechanisms of stretch activation in mammalian striated muscle
(University of Missouri--Columbia, 2017)
Stretch activation is described as a delayed increase in force after an imposed stretch. This process is essential in the flight muscles of many insects and is also observed, to some degree, in mammalian striated muscles. ...
Chlorinated lipid induce inflammatory responses in the microcirculation
(University of Missouri--Columbia, 2017)
Previous studies from our research group have shown that chlorinated lipid, generated from the neutrophil-myeloperoxidase (MPO) system, are elevated in a rat sepsis model as well as in plasma of septic patients. Other work ...
Role of T-type Ca²⁺ channels in lymphatic pacemaking /
(University of Missouri--Columbia, 2017)
transport in lymphatic-related diseases such as lymphedema. Understanding the pacemaking mechanism of LSM that underlies active lymph transport is essential for therapeutic targeting of lymphedema. Based on experiments using pharmacological inhibitors...
Physiological and pharmacological characterization of the N1303K mutant CFTR
(University of Missouri--Columbia, 2018)
associated with the N1303K mutation and its pharmacological response to CFTR modulators including potentiators VX-770 and GLPG1837 and correctors VX-809, and VX-661. Methods: Gating behavior and pharmacological responses to CFTR potentiators were assessed...
Integrin adhesion response to chemical and mechanical stimulation
(University of Missouri--Columbia, 2017)
It is well recognized that arterial stiffness increases with aging and aging-related diseases, such as hypertension. The mechanisms for the increase in stiffness have been largely thought to be the result of changes in the ...