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Role of adropin in arterial stiffening associated with obesity and type 2 diabetes
(University of Missouri--Columbia, 2022)
Adropin is a peptide largely secreted by the liver and known to regulate energy homeostasis; however, it also exerts cardiovascular effects. Herein, I tested the hypothesis that low circulating levels of adropin in obesity and type 2 diabetes (T2D...
Investigating increased shear stress and physical activity as strategies to improve vascular insulin sensitivity
(University of Missouri--Columbia, 2020)
by participation in an eight-week exercise program, in the form of increased walking, was interrogated. Despite an improvement in popliteal artery flow-mediated dilation, microvascular insulin resistance was not improved in T2D following an eight-week walking...
The role of heat shock protein 72 in endothelial insulin resistance in type 2 diabetes: using passive heat therapy to improve endothelial insulin responsiveness
(University of Missouri--Columbia, 2022)
Impaired endothelial insulin signaling and consequent blunting of insulin-induced vasodilation is a feature of type 2 diabetes (T2D) and contributes to vascular disease and glycemic dysregulation. However, the molecular mechanisms underlying...
The brown adipose tissue phenoype : metabolic implications
(University of Missouri--Columbia, 2018)
protein 1, cold tolerance, and BAT respiration) via mild cold stress (i.e., 20 [degrees] C) does not improve glucose tolerance in diet-induced obese mice; (ii) genetic silencing of the Pnpla2 in interscapular BAT causes a brown-to-white like phenotypic...