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The role of creatine supplementation and mTORC1 signaling in ameliorating cognitive deficiency in a neuroinflammatory rat model
(University of Missouri--Columbia, 2022)
proteins, PSD-95 and synapsin, in dentate gyrus but not in medial prefrontal cortex. Immunohistochemistry analysis revealed upregulation of mTORC1 in NeuN+ neurons. Importantly, selective inhibition of mTORC1 signaling through rapamycin attenuated...
Evaluating the molecular drivers of physical inactivity and muscle atrophy as initiating factors in cognitive impairment
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 8/1/2024] Physical activity has played an essential role in the evolution of humans and the development of the human brain. Therefore, it comes as no surprise that the modern-day pandemic levels of sedentarism ...