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Toward polar 1,4-diphenylbutadiene materials
(University of Missouri--Columbia, 2004)
now been studied. In Chapter 1, we illustrate the difficulty of achieving dipole parallel-aligned crystals, the solution to the problem, and the research in our group. In Chapter 2, (E,E)-1,4-diphenyl-1,3-butadiene is analyzed by computations in gas...
Design and construction of multicomponent spheroidal assemblies on the nano-scale via the self-assembly approach
(University of Missouri--Columbia, 2006)
together by numerous hydrogen bonds and enclose approximately 1200 [angstrom][superscript 3] of inner space. Chapter 3 will discuss a new design approach to large multicomponent metalligand coordination capsules. All the metal-directed self-assembly methods...
Molecular basis of protein tyrosine phosphatase inhibition by biologically important small molecules with relevance to cell signaling pathways
(University of Missouri--Columbia, 2009)
Protein tyrosine phosphatase 1B (PTP1B) is an abundant mammalian enzyme and well known to be as a central player in the insulin and leptin signaling pathways. Peracetic acid is a strong oxidant molecule, endogenously produced by mammalian...
Computational studies of three chemical systems
(University of Missouri--Columbia, 2011)
are examined to better understand the process by which self-assembly of the nanocapsule occurs. The second topic is the study of the addition of H2O and O2 to vanadyl complexes of the form [VOX(NCCH3)]+ where X = F-, Cl-, Br-, I-, and OH-. Changing the identity...
Prospective radiolabled bombesin conjugates for prostate cancer imaging and therapeutic agents
(University of Missouri--Columbia, 2009)
An active area of prostate cancer research is in the synthesis of radiolabeled peptides for in vivo tumor imaging or therapy. This method is possible since specific receptors are expressed in high concentration on certain ...
Inactivation of protein tyrosine phosphatases by endogenous and dietary agents
(University of Missouri--Columbia, 2009)
disrupting signaling pathways inside cells. It is possible that these small molecules are exerting their widely reported biological effect by the modification of protein tyrosine phosphatase activity. This information is critical to our understanding...
Ammonia elimination from protonated nucleobases
(University of Missouri--Columbia, 2007)
The dediazoniations of the diazonium ion 1 of 4-aminopyrimidine and of the tautomeric cytosinediazonium ions 2 and 3 are facile and result in the formations of cations 4, 5, and 6. The pyrimidine ring-opening of 4, 5 and 6 form their acyclic isomers...
Aza-analogues of distyrylbenzene (DSB) synthesis, structures, and properties of 1,4-phenylenediamine bisimines (PDABI)
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The drive for electo-optically active materials was officially initiated in 1966 with the publishing, by NASA, of a 137 page report. The "Electro-optic Projection Study" outlined...
The effects of structural modifications on sigma receptor binding
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family that has two subtypes: sigma1 and sigma2. Sigma1 receptors are involved in several physiological functions such as psychosis and depression. Sigma2 receptors are expressed in ...
Synthesis of silyloxyacrolein for [4+3] cycloaddition and preparation of carbonate closomer
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Followed by Funk's method, I synthesized silyloxyacroleins and used them as dienophiles to react with different dienes in [4+3] cycloaddition reaction. These enals such as 2...
The synthesis and characterization of 1,1'-disubstituted ferrocene imine Schiff base ligand systems for use as potential environmental heavy metal cationic sensors
(University of Missouri--Columbia, 2008)
cation. One reported and two unreported 1,1'-disubstituted ferrocene systems have been tested with eight metals and their complexes characterized as a means to develop a spectroscopic database. The information can be used to determine the products formed...
Anisotropic organic materials : ferroelectric crystals and spin-polarized radicals
(University of Missouri--Columbia, 2007)
,4-diphenyl-1,3-butadiene is analyzed with various methods. Toward quasienantiomeric non-linear crystals, 1- methyl-1,3,6-triphenyl-7-(E-2-phenylpropenyl)-1,2-dihydronaphthalene is probed in molecular interactions, synthesis, and chiral separation. In Chapter...
Studies of the chemistry of Tröger's base, cyclopentadienones, and 2,1-benzothiazines
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The sequential alkylation of Tröger's base was developed for the synthesis of symmetric dialkylation analogs. The products from this reaction were ...
Strategies for metal colloidal nancrystal synthesis in sustainable media
(University of Missouri--Columbia, 2019)
and functionalities of such nanomaterials. This dissertation reports strategies for metal colloidal nanocrystal synthesis in sustainable media and aims to build a foundation for understanding how to tailor eco-friendly IL and DES fluids to control the growth of metal...
Biologically relevant chemistry of sulfur heterocycles : from redox regulation of PTP1B to the biological activity of s-deoxy leinamycin
(University of Missouri--Columbia, 2008)
Protein tyrosine phosphatase 1B (PTP1B) is an important member of protein tyrosine phosphatase (PTPs) family that shares a conserved catalytic cysteine thiol residue. PTP1B acts as a negative regulator of insulin mediated signaling cascade...
Core-based hyperbranched polyethyleneimine coating in capillary electrophoresis
(University of Missouri--Columbia, 2009)
. In CHPEI-coated capillaries, several parameters were studied as follows: (1) EOF as a function of buffer pH; (2) effect of coating media (NaCl solution) concentration; (3) effect of buffer concentration; and (4) stability and reproducibility of the coating...
Probing supramolecular assemblies via fluorescent reporter molecules
(University of Missouri--Columbia, 2007)
the organization of the capsule interior when fluorescent reporter molecules, (1-(9-anthryl)-3-(4-dimethylaniline) propane) and pyrene butyric acid, became entrapped. Solution state spectroscopic data, in agreement with solid state single crystal X...
Study of the chemistry of 2,1-benzothiazines and toward the total synthesis of elisapterosin B
(University of Missouri--Columbia, 2009)
in addition to the expected six-membered rings. Several attempts have been tried to approach the total synthesis of elisapterosin B, an important antitubercular and antimalarial marine natural product. Several methods have been tested: a diastereoselective...
(4+3)-cycloaddition chemists of oxidopyridinium ions and related study
(University of Missouri--Columbia, 2019)
The (4+3)-cycloaddition reaction is a cycloaddition between a 4-atom species and a 3-atom species to form a seven-membered ring. This reaction results in the formation of seven-membered rings. Our research expanded the scope of (4+3)-cycloaddition...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...