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Characterization of D-boroala as a novel Broad-spectrum antibacterial agent targeting D-Ala-D-Ala ligase & designer linkers : model reactions and linear free energy relationships in the reactivity and design of solid-phase linkers
(2014-07-18)
efforts to develop transition-state analog inhibitors for bacterial cell wall–synthesizing enzymes, we observed that D-boroAlanine (D-Ala with the -COOH group replaced with a -B(OH)2 group) had effective antibacterial activity. In the first part...
Metabolomics and chemical library screening for antibacterial drug discovery
(2020)
-family dioxygenases (TET1, TET2 and TET3) initiate active demethylation of 5mC. TET2 oxidizes 5mC into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) by iterative oxidation. Mutations in the TET2 gene are frequently detected...
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)
) and its microsome metabolized (pre-metabolized; PM) forms, and in the absence and presence of vancomycin. This allows the identification of agents with active metabolites and agents that can act synergistically with the resistant-to-antibiotic. 2 x 2...
Metabolomic Analysis of Bacterial Cell Wall Intermediates Using LC-MS/MS: Peptidoglycan Pathway Response to Different Antibiotics
(University of Missouri--Kansas City, 2017)
The bacterial cell wall is made up of peptidoglycan (PG) and its synthesis is of
interest as a target for several antibiotics and for new inhibitor development. Peptidoglycan
biosynthesis is a complex process which ...