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The role of creatine supplementation and mTORC1 signaling in ameliorating cognitive deficiency in a neuroinflammatory rat model
(University of Missouri--Columbia, 2022)
involved in the pathology of dementia. One promising intervention may appear to be beneficial for MCI is creatine (Cr), which has been proven to be effective for ameliorating cognitive deficiency in general. However, it is unclear whether Cr supplementation...
Evaluating the molecular drivers of physical inactivity and muscle atrophy as initiating factors in cognitive impairment
(University of Missouri--Columbia, 2023)
decreased Glutamate AMPA Receptor 1 (GluA1) protein levels, and neurogenesis. Our genetic model for high physical activity on the other hand had enhanced performance in cognitive behavioral testing, increased hippocampal volumes, and increased markers...