Search
Now showing items 1-5 of 5
Unraveling the role of the endogenous complex gut microbiota in the Pirc rat model of human colon cancer
(University of Missouri--Columbia, 2018)
relative abundances showed taxa correlating with suppression of both tumor growth and phenotype penetrance as early as 1 month of age. To determine the role of individual bacteria Pirc rats were treated with 3 different bacteria associated with reduced...
Mechanisms of clostridial toxin binding and translocation
(University of Missouri--Columbia, 2018)
that targeted mutations within the Sia5 binding pocket result in the generation of neurotoxins that either bind and enter cells more efficiently (BoNT/A1 and BoNT/B) or display altered ganglioside binding specificity (TeNT). These data support a model in which...
Interactions between helicobacter-induced inflammation acute changes in the gut microbiota, and colorectal cancer in Smad3-/- mice
(University of Missouri--Columbia, 2020)
harboring distinct GM profiles termed GM1, GM2, and GM4 were similarly inoculated with Helicobacter spp. and followed longitudinally through disease development or lack thereof. We hypothesized that GM1 and 2 would develop the most severe disease, due...
Establishing the posh scaffold as a novel therapeutic target for treatment of B cell leukemia
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] More than 60,000 new cases of leukemia will be diagnosed in the U.S. this year. B cells comprise 10 [percent] of acute lymphoblastic leukemias ...
Duchenne muscular dystrophy gene therapy in the canine model
(University of Missouri--Columbia, 2018)
structural protein in muscle. DMD is the most common form of inherited muscle disease in childhood, with an incidence of 1 in 5000 live male births worldwide. The dystrophin-null mdx mouse has been the most widely used animal model for DMD research over...