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Isotope harvesting from the beam dump cooling loop at the facility for rare isotope beams (FRIB)
(University of Missouri--Columbia, 2018)
column volumes of strong acid for elution. V was chosen as a radiotracer to determine the feasibility of using HFSLM extraction to remove short-lived transition metals from the beam dump loop. Part per trillion levels of 48V were successfully recovered...
Radionuclide production and separation techniques for radiopharmaceutical development and nuclear waste processing
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] With increasing cancer incident rates and advancements in nuclear medicine, the demand for optimizing pathways to produce radionuclides or investigating ...
Arsenic-72, 77 as a matched pair radiopharmaceutical for imaging and radiotherapy
(University of Missouri--Columbia, 2018)
] The parameters for a 72Se/72As generator were evaluated and nca 72Se was produced via the 70Ge([alpha], 2n)72Se nuclear reaction, separated and loaded onto a generator column. Further evaluations are underway. Radiochemistry of nca 72,77As will be discussed...
Studies and synthetic methodology of Nampt inhibition
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The purpose of this research is to study and synthesize an array of a highly potent pharmaceuticals that can selectively cause apoptosis in various ...
DNA interstrand crosslinks arising from DAN strand breaks at true abasic sites in duplex DNA
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Abasic sites (apurinic/apyrimidinic sites, Ap sites) are one of the most common forms of lesions found in genomic DNA. For the past decade, Gates group ...
Development of radiolabeled metal chalcogenide nanoparticles for targeted adiotherapy against an infection
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Targeted radiotherapy has been demonstrated to be therapeutic against infections with doses comparable to what a patient would receive for cancer ...
Synthesis and reactivity of actinide phosphorano-stabilized carbene and phosphido complexes
(University of Missouri--Columbia, 2018)
the use of phosphorano-stabilized carbene complexes to make short actinide-carbon bonds. In fact, these complexes exhibit the shortest uranium and thorium-carbon bonds reported in the literature. Chapter 3 revolves around investigating the synthesis...
The use of pluripotent stem cells as a model for early human placentation
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Throughout gestation, the placenta plays a critical role in ensuring proper development of the fetus. The placenta functions to exchange nutrients, ...
Atomic-scale studies of chemical and transport processes relevant to propellant combustion
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Density functional theory (DFT) and correlated molecular orbital electronic structure calculations were used to study the Al + CO2 [subscript arrow] ...